Design, methods, and conduct of the optic neuritis treatment trial

The Optic Neuritis Study Group

Research output: Contribution to journalArticle

Abstract

The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intravenous methylprednisolone followed by oral prednisone as compared with oral placebo. The primary outcome measures were contrast sensitivity and visual field; secondary measures were visual acuity and color vision. Four hundred fifty-seven patients were followed for a minimum of 6 months and a maximum of 3 years. This article describes the design and the methods used to implement the ONTT.

Original languageEnglish (US)
Pages (from-to)123-142
Number of pages20
JournalControlled Clinical Trials
Volume14
Issue number2
DOIs
StatePublished - Jan 1 1993

Keywords

  • Controlled clinical trial
  • optic neuritis
  • randomized trial

ASJC Scopus subject areas

  • Pharmacology

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