Design characteristics for temporomandibular joint disc tissue engineering

Learning from tendon and articular cartilage

D. E. Johns, K. A. Athanasiou

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Tissue engineering of chondrocytic or fibroblastic musculoskeletal tissues has been relatively well studied compared with that of the temporomandibular joint (TMJ) disc. Early attempts at tissue engineering the disc have been misguided owing to a lack of understanding of the composition and function of the TMJ disc. The objective of this review is to compare the TMJ disc with a chondrocytic tissue (hyaline articular cartilage) and a fibroblastic tissue (tendon) to understand better the properties of this fibrocartilaginous tissue. The TMJ disc has 25 times more glycosaminoglycan (GAG) per dry weight than tendon but half that of articular cartilage. The disc's tensile modulus is six times more than cartilage but orders less than tendon. The GAG content and tensile modulus suggest that the TMJ disc is characterized as a tissue between hyaline cartilage and tendon, but the disc appears more tendon like when considering its collagen make-up and cell content. Like tendon, the TMJ disc contains primarily collagen type I at 85 per cent per dry weight, while articular cartilage has 30 per cent less collagen, which is type II. Knowledge of quantitative comparisons between joint tissues can give extensive insight into how to improve tissue engineering of the TMJ disc.

Original languageEnglish (US)
Pages (from-to)509-526
Number of pages18
JournalProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
Volume221
Issue number5
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Tendons
Cartilage
Tissue engineering
Tissue
Collagen
Elastic moduli
Temporomandibular Joint
Chemical analysis

Keywords

  • Articular cartilage
  • Characterization
  • Extracellular matrix
  • Mechanical properties
  • Temporomandibular joint
  • Tendon
  • Tissue engineering

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanical Engineering

Cite this

@article{94af867e02c4448e89d1739eae1b7e3b,
title = "Design characteristics for temporomandibular joint disc tissue engineering: Learning from tendon and articular cartilage",
abstract = "Tissue engineering of chondrocytic or fibroblastic musculoskeletal tissues has been relatively well studied compared with that of the temporomandibular joint (TMJ) disc. Early attempts at tissue engineering the disc have been misguided owing to a lack of understanding of the composition and function of the TMJ disc. The objective of this review is to compare the TMJ disc with a chondrocytic tissue (hyaline articular cartilage) and a fibroblastic tissue (tendon) to understand better the properties of this fibrocartilaginous tissue. The TMJ disc has 25 times more glycosaminoglycan (GAG) per dry weight than tendon but half that of articular cartilage. The disc's tensile modulus is six times more than cartilage but orders less than tendon. The GAG content and tensile modulus suggest that the TMJ disc is characterized as a tissue between hyaline cartilage and tendon, but the disc appears more tendon like when considering its collagen make-up and cell content. Like tendon, the TMJ disc contains primarily collagen type I at 85 per cent per dry weight, while articular cartilage has 30 per cent less collagen, which is type II. Knowledge of quantitative comparisons between joint tissues can give extensive insight into how to improve tissue engineering of the TMJ disc.",
keywords = "Articular cartilage, Characterization, Extracellular matrix, Mechanical properties, Temporomandibular joint, Tendon, Tissue engineering",
author = "Johns, {D. E.} and Athanasiou, {K. A.}",
year = "2007",
doi = "10.1243/09544119JEIM158",
language = "English (US)",
volume = "221",
pages = "509--526",
journal = "Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine",
issn = "0954-4119",
publisher = "SAGE Publications Ltd",
number = "5",

}

TY - JOUR

T1 - Design characteristics for temporomandibular joint disc tissue engineering

T2 - Learning from tendon and articular cartilage

AU - Johns, D. E.

AU - Athanasiou, K. A.

PY - 2007

Y1 - 2007

N2 - Tissue engineering of chondrocytic or fibroblastic musculoskeletal tissues has been relatively well studied compared with that of the temporomandibular joint (TMJ) disc. Early attempts at tissue engineering the disc have been misguided owing to a lack of understanding of the composition and function of the TMJ disc. The objective of this review is to compare the TMJ disc with a chondrocytic tissue (hyaline articular cartilage) and a fibroblastic tissue (tendon) to understand better the properties of this fibrocartilaginous tissue. The TMJ disc has 25 times more glycosaminoglycan (GAG) per dry weight than tendon but half that of articular cartilage. The disc's tensile modulus is six times more than cartilage but orders less than tendon. The GAG content and tensile modulus suggest that the TMJ disc is characterized as a tissue between hyaline cartilage and tendon, but the disc appears more tendon like when considering its collagen make-up and cell content. Like tendon, the TMJ disc contains primarily collagen type I at 85 per cent per dry weight, while articular cartilage has 30 per cent less collagen, which is type II. Knowledge of quantitative comparisons between joint tissues can give extensive insight into how to improve tissue engineering of the TMJ disc.

AB - Tissue engineering of chondrocytic or fibroblastic musculoskeletal tissues has been relatively well studied compared with that of the temporomandibular joint (TMJ) disc. Early attempts at tissue engineering the disc have been misguided owing to a lack of understanding of the composition and function of the TMJ disc. The objective of this review is to compare the TMJ disc with a chondrocytic tissue (hyaline articular cartilage) and a fibroblastic tissue (tendon) to understand better the properties of this fibrocartilaginous tissue. The TMJ disc has 25 times more glycosaminoglycan (GAG) per dry weight than tendon but half that of articular cartilage. The disc's tensile modulus is six times more than cartilage but orders less than tendon. The GAG content and tensile modulus suggest that the TMJ disc is characterized as a tissue between hyaline cartilage and tendon, but the disc appears more tendon like when considering its collagen make-up and cell content. Like tendon, the TMJ disc contains primarily collagen type I at 85 per cent per dry weight, while articular cartilage has 30 per cent less collagen, which is type II. Knowledge of quantitative comparisons between joint tissues can give extensive insight into how to improve tissue engineering of the TMJ disc.

KW - Articular cartilage

KW - Characterization

KW - Extracellular matrix

KW - Mechanical properties

KW - Temporomandibular joint

KW - Tendon

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=34548139303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548139303&partnerID=8YFLogxK

U2 - 10.1243/09544119JEIM158

DO - 10.1243/09544119JEIM158

M3 - Article

VL - 221

SP - 509

EP - 526

JO - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

JF - Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

SN - 0954-4119

IS - 5

ER -