Design and synthesis of mimics of the T7-loop of FtsZ

Nohemy A. Sorto; Phillip P. Painter; James C. Fettinger; Dean J. Tantillo; Jared T. Shaw

doi:10.1021/ol4010068

Design and synthesis of mimics of the T7-loop of FtsZ

Nohemy A. Sorto, Phillip P. Painter, James C. Fettinger, Dean J. Tantillo, Jared T. Shaw

Chemistry

Research output: Contribution to journal › Article

7 Scopus citations

Abstract

Mimics of the T7-loop of the bacterial cell division protein FtsZ have been designed and synthesized. The design is based on the X-ray cocrystal structure of P. aeruginosa FtsZ:SulA. Fast Rigid Exhaustive Docking (FRED) was employed to select compounds that can mimic the key interacting residues. Bicyclic oxazolidinones 1a-d were selected for further study and synthesized from a key bicyclic aziridine intermediate, which is synthesized from a readily available unsaturated aldehyde and amides derived from α-amino acids.

Original language	English (US)
Pages (from-to)	2700-2703
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	11
DOIs	https://doi.org/10.1021/ol4010068
State	Published - 2013

ASJC Scopus subject areas

Organic Chemistry
Physical and Theoretical Chemistry
Biochemistry

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10.1021/ol4010068

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Sorto, N. A., Painter, P. P., Fettinger, J. C., Tantillo, D. J., & Shaw, J. T. (2013). Design and synthesis of mimics of the T7-loop of FtsZ. Organic Letters, 15(11), 2700-2703. https://doi.org/10.1021/ol4010068

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AU - Tantillo, Dean J.

AU - Shaw, Jared T.

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