Design and synthesis of mimics of the T7-loop of FtsZ

Nohemy A. Sorto, Phillip P. Painter, James C. Fettinger, Dean J. Tantillo, Jared T. Shaw

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Mimics of the T7-loop of the bacterial cell division protein FtsZ have been designed and synthesized. The design is based on the X-ray cocrystal structure of P. aeruginosa FtsZ:SulA. Fast Rigid Exhaustive Docking (FRED) was employed to select compounds that can mimic the key interacting residues. Bicyclic oxazolidinones 1a-d were selected for further study and synthesized from a key bicyclic aziridine intermediate, which is synthesized from a readily available unsaturated aldehyde and amides derived from α-amino acids.

Original languageEnglish (US)
Pages (from-to)2700-2703
Number of pages4
JournalOrganic Letters
Volume15
Issue number11
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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    Sorto, N. A., Painter, P. P., Fettinger, J. C., Tantillo, D. J., & Shaw, J. T. (2013). Design and synthesis of mimics of the T7-loop of FtsZ. Organic Letters, 15(11), 2700-2703. https://doi.org/10.1021/ol4010068