Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin

Wen Wei Qiu, Jie Xu, Da Liu, Jing Ya Li, Yang Ye, Xing Zu Zhu, Jia Li, Fa Jun Nan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A trifunctional probe (binding element-photoreactive group-affinity tag) of natural product paeoniflorin was designed and synthesized based on the previous primary structure-activity relationship. This new probe is a potential tool for labeling, purification, and identification of the target proteins.

Original languageEnglish (US)
Pages (from-to)3306-3309
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number12
DOIs
StatePublished - Jun 15 2006
Externally publishedYes

Fingerprint

Structure-Activity Relationship
Biotin
Biological Products
Labeling
Purification
Proteins
peoniflorin

Keywords

  • Paeoniflorin
  • Photoaffinity probe
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin. / Qiu, Wen Wei; Xu, Jie; Liu, Da; Li, Jing Ya; Ye, Yang; Zhu, Xing Zu; Li, Jia; Nan, Fa Jun.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 12, 15.06.2006, p. 3306-3309.

Research output: Contribution to journalArticle

Qiu, Wen Wei ; Xu, Jie ; Liu, Da ; Li, Jing Ya ; Ye, Yang ; Zhu, Xing Zu ; Li, Jia ; Nan, Fa Jun. / Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 12. pp. 3306-3309.
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