Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin

Wen Wei Qiu, Jie Xu, Da Liu, Jing Ya Li, Yang Ye, Xing Zu Zhu, Jia Li, Fa Jun Nan

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A trifunctional probe (binding element-photoreactive group-affinity tag) of natural product paeoniflorin was designed and synthesized based on the previous primary structure-activity relationship. This new probe is a potential tool for labeling, purification, and identification of the target proteins.

Original languageEnglish (US)
Pages (from-to)3306-3309
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number12
DOIs
StatePublished - Jun 15 2006
Externally publishedYes

Keywords

  • Paeoniflorin
  • Photoaffinity probe
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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