Design and fabrication of disposable, percutaneous chemical sensors

Kuo Chih Liao, Thieo Hogen-Esch, Frances J. Richmond, Laura Marcu, Gerald E. Loeb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

Sencils™ (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophors bound to dextran and Concanavalin-A in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-500mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsI. Gannot
Pages129-145
Number of pages17
Volume5691
DOIs
StatePublished - 2005
Externally publishedYes
EventOptical Fibers and Sensors for Medical Applications V - San Jose, CA, United States
Duration: Jan 22 2005Jan 25 2005

Other

OtherOptical Fibers and Sensors for Medical Applications V
CountryUnited States
CitySan Jose, CA
Period1/22/051/25/05

Keywords

  • Affinity-binding assay
  • Chemical sensor
  • Fluorescence resonance energy transfer
  • Glucose
  • Optical fiber
  • Quantum dots

ASJC Scopus subject areas

  • Engineering(all)

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