Design and fabrication of a disposable, percutaneous glucose sensor

Kuo Chih Liao, Thieo Hogen-Esch, Frances J. Richmond, Laura Marcu, William Clifton, Gerald E. Loeb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Sencils™ (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophores bound to betacyclodextrin and Concanavalin A (Con A) in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-580mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6083
DOIs
StatePublished - 2006
Externally publishedYes
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI - San Jose, CA, United States
Duration: Jan 21 2006Jan 22 2006

Other

OtherOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI
CountryUnited States
CitySan Jose, CA
Period1/21/061/22/06

Fingerprint

Glucose sensors
Fabrication
Glucose
Fluorophores
Chemical sensors
Polymer matrix
Biocompatibility
Photonics
Polyethylene glycols
Optical fibers
Chemical reactions
Fluids
Fibers
Experiments

Keywords

  • Affinity-binding assay
  • Chemical sensor
  • Fluorescence resonance energy transfer
  • Glucose
  • Optical fiber
  • Quantum dots

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Liao, K. C., Hogen-Esch, T., Richmond, F. J., Marcu, L., Clifton, W., & Loeb, G. E. (2006). Design and fabrication of a disposable, percutaneous glucose sensor. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6083). [60830V] https://doi.org/10.1117/12.643990

Design and fabrication of a disposable, percutaneous glucose sensor. / Liao, Kuo Chih; Hogen-Esch, Thieo; Richmond, Frances J.; Marcu, Laura; Clifton, William; Loeb, Gerald E.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6083 2006. 60830V.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Liao, KC, Hogen-Esch, T, Richmond, FJ, Marcu, L, Clifton, W & Loeb, GE 2006, Design and fabrication of a disposable, percutaneous glucose sensor. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6083, 60830V, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI, San Jose, CA, United States, 1/21/06. https://doi.org/10.1117/12.643990
Liao KC, Hogen-Esch T, Richmond FJ, Marcu L, Clifton W, Loeb GE. Design and fabrication of a disposable, percutaneous glucose sensor. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6083. 2006. 60830V https://doi.org/10.1117/12.643990
Liao, Kuo Chih ; Hogen-Esch, Thieo ; Richmond, Frances J. ; Marcu, Laura ; Clifton, William ; Loeb, Gerald E. / Design and fabrication of a disposable, percutaneous glucose sensor. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6083 2006.
@inproceedings{9c7d9b963d68409e813ddb0898d99ce7,
title = "Design and fabrication of a disposable, percutaneous glucose sensor",
abstract = "Sencils™ (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophores bound to betacyclodextrin and Concanavalin A (Con A) in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-580mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.",
keywords = "Affinity-binding assay, Chemical sensor, Fluorescence resonance energy transfer, Glucose, Optical fiber, Quantum dots",
author = "Liao, {Kuo Chih} and Thieo Hogen-Esch and Richmond, {Frances J.} and Laura Marcu and William Clifton and Loeb, {Gerald E.}",
year = "2006",
doi = "10.1117/12.643990",
language = "English (US)",
isbn = "0819461253",
volume = "6083",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Design and fabrication of a disposable, percutaneous glucose sensor

AU - Liao, Kuo Chih

AU - Hogen-Esch, Thieo

AU - Richmond, Frances J.

AU - Marcu, Laura

AU - Clifton, William

AU - Loeb, Gerald E.

PY - 2006

Y1 - 2006

N2 - Sencils™ (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophores bound to betacyclodextrin and Concanavalin A (Con A) in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-580mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

AB - Sencils™ (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophores bound to betacyclodextrin and Concanavalin A (Con A) in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-580mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

KW - Affinity-binding assay

KW - Chemical sensor

KW - Fluorescence resonance energy transfer

KW - Glucose

KW - Optical fiber

KW - Quantum dots

UR - http://www.scopus.com/inward/record.url?scp=33646189212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646189212&partnerID=8YFLogxK

U2 - 10.1117/12.643990

DO - 10.1117/12.643990

M3 - Conference contribution

AN - SCOPUS:33646189212

SN - 0819461253

SN - 9780819461254

VL - 6083

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -