Design and fabrication of a disposable, percutaneous glucose sensor

Kuo Chih Liao, Thieo Hogen-Esch, Frances J. Richmond, Laura Marcu, William Clifton, Gerald E. Loeb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Sencils™ (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophores bound to betacyclodextrin and Concanavalin A (Con A) in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-580mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6083
DOIs
StatePublished - 2006
Externally publishedYes
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI - San Jose, CA, United States
Duration: Jan 21 2006Jan 22 2006

Other

OtherOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI
CountryUnited States
CitySan Jose, CA
Period1/21/061/22/06

Keywords

  • Affinity-binding assay
  • Chemical sensor
  • Fluorescence resonance energy transfer
  • Glucose
  • Optical fiber
  • Quantum dots

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Liao, K. C., Hogen-Esch, T., Richmond, F. J., Marcu, L., Clifton, W., & Loeb, G. E. (2006). Design and fabrication of a disposable, percutaneous glucose sensor. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6083). [60830V] https://doi.org/10.1117/12.643990