Design and development of an MR-compatible PET scanner for imaging small animals

Jane E. Mackewn, D. Strul, W. A. Hallett, P. Halsted, R. A. Page, S. F. Keevil, S. C R Williams, Simon R Cherry, P. K. Marsden

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

A single-slice magnetic resonance (MR) compatible positron emission tomography (PET) system with a transaxial field of view ∼6 cm has been designed and is currently under construction. It will consist of four concentric rings of lutetium oxyorthosilicate (LSO) scintillation crystals, each coupled to one of eight multi-channel photomultplier tubes (PMTs) via 3.5 m optical fibers. The annulus containing the crystals has an outside diameter of 12 cm and is placed within the MR field of view whilst the PMTs are located outside the main magnetic field. A highly re-producible method that optimizes the amount of scintillation light that reaches the PMTs has been established. Two small sections of the scanner, each containing 4 by 4 crystal arrays, demonstrated good flood position histograms with all sixteen channels clearly identifiable. The light loss through a fiber of length of 3.25 m was approximately 70%. The spatial resolution of the two arrays in coincidence was measured at 1.6 mm full-width half-maximum (FWHM), and the temporal resolution of one array in coincidence with a single LSO crystal was measured to be 10.9 ns. The design incorporates a novel technique for improving sampling at the center of the field of view within the scanner. The concentric rings are offset with respect to one another by one quarter of the crystal width between layers resulting in significantly improved sampling. The results indicate that the PET scanner will have a performance comparable with that of current small animal systems and it will be used to investigate the utility and potential applications of combining PET and MR in small animals.

Original languageEnglish (US)
Pages (from-to)1376-1380
Number of pages5
JournalIEEE Transactions on Nuclear Science
Volume52
Issue number5 I
DOIs
StatePublished - Oct 2005

Fingerprint

Positron emission tomography
Magnetic resonance
scanners
magnetic resonance
animals
positrons
Animals
tomography
field of view
Imaging techniques
Crystals
Scintillation
tubes
scintillation
crystals
sampling
Sampling
Lutetium
lutetium
rings

Keywords

  • Dectecors
  • Magnetic resonance
  • Multimodality
  • Positron emission tomography
  • Sampling

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Mackewn, J. E., Strul, D., Hallett, W. A., Halsted, P., Page, R. A., Keevil, S. F., ... Marsden, P. K. (2005). Design and development of an MR-compatible PET scanner for imaging small animals. IEEE Transactions on Nuclear Science, 52(5 I), 1376-1380. https://doi.org/10.1109/TNS.2005.858260

Design and development of an MR-compatible PET scanner for imaging small animals. / Mackewn, Jane E.; Strul, D.; Hallett, W. A.; Halsted, P.; Page, R. A.; Keevil, S. F.; Williams, S. C R; Cherry, Simon R; Marsden, P. K.

In: IEEE Transactions on Nuclear Science, Vol. 52, No. 5 I, 10.2005, p. 1376-1380.

Research output: Contribution to journalArticle

Mackewn, JE, Strul, D, Hallett, WA, Halsted, P, Page, RA, Keevil, SF, Williams, SCR, Cherry, SR & Marsden, PK 2005, 'Design and development of an MR-compatible PET scanner for imaging small animals', IEEE Transactions on Nuclear Science, vol. 52, no. 5 I, pp. 1376-1380. https://doi.org/10.1109/TNS.2005.858260
Mackewn, Jane E. ; Strul, D. ; Hallett, W. A. ; Halsted, P. ; Page, R. A. ; Keevil, S. F. ; Williams, S. C R ; Cherry, Simon R ; Marsden, P. K. / Design and development of an MR-compatible PET scanner for imaging small animals. In: IEEE Transactions on Nuclear Science. 2005 ; Vol. 52, No. 5 I. pp. 1376-1380.
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