Design and Construction of the Automatic Peptide Library Synthesizer

Z. Barták, J. Bolf, J. Kalousek, P. Mudra, M. Pavlík, V. Pokorný, M. Rinnová, Z. Vobůrka, K. Ženíšek, V. Krchňák, M. Lebl, S. E. Salmon, Kit Lam

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

An automatic peptide library synthesizer capable of randomizing 20 building blocks in 20 reaction vessels is described. The design is based on uniform bead distribution by gravity sedimentation after thorough mixing by inert gas bubbling and stirring. The instrument can be alternatively used as a multiple peptide synthesizer since it can deliver any reagent to any reaction vessel.

Original languageEnglish (US)
Pages (from-to)432-437
Number of pages6
JournalMethods
Volume6
Issue number4
DOIs
StatePublished - Dec 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology

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    Barták, Z., Bolf, J., Kalousek, J., Mudra, P., Pavlík, M., Pokorný, V., Rinnová, M., Vobůrka, Z., Ženíšek, K., Krchňák, V., Lebl, M., Salmon, S. E., & Lam, K. (1994). Design and Construction of the Automatic Peptide Library Synthesizer. Methods, 6(4), 432-437. https://doi.org/10.1006/meth.1994.1046