Description of an albumin binding activity for Streptococcus suis serotype 2

Sylvain Quessy, Philippe Busque, Robert Higgins, Mario Jacques, J. Daniel Dubreuil

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

This study was undertaken to investigate the binding activity of Streptococcus suis serotype 2 to albumin. Using flow cytometry we observed a binding activity of S. suis to albumin for virulent as well as for avirulent isolates. Western immunoblots analysis revealed that a 39-kDa S. suis protein was responsible, at least in part, for this binding activity. This protein showed high N-terminal homology (95.6% for the first 23 residues) with a group A Streptococcus glyceraldehyde-3-phosphate dehydrogenase. Furthermore, the addition of albumin to the culture broth resulted in an increase in the virulence of S. suis strains in mice. These results suggest that an interaction with albumin could play a role in the pathogenesis of S. suis serotype 2 infections.

Original languageEnglish (US)
Pages (from-to)245-250
Number of pages6
JournalFEMS Microbiology Letters
Volume147
Issue number2
DOIs
StatePublished - Feb 15 1997
Externally publishedYes

Keywords

  • albumin
  • binding protein
  • Streptococcus suis

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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