Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

Vivek Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, David A. Boas

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

Original languageEnglish (US)
Pages (from-to)3086-3088
Number of pages3
JournalOptics Letters
Volume34
Issue number20
DOIs
StatePublished - Oct 15 2009
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Srinivasan, V., Sakadžić, S., Gorczynska, I., Ruvinskaya, S., Wu, W., Fujimoto, J. G., & Boas, D. A. (2009). Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. Optics Letters, 34(20), 3086-3088. https://doi.org/10.1364/OL.34.003086