Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

Vivek Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, David A. Boas

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

Original languageEnglish (US)
Pages (from-to)3086-3088
Number of pages3
JournalOptics Letters
Volume34
Issue number20
DOIs
StatePublished - Oct 15 2009
Externally publishedYes

Fingerprint

hemodynamics
tomography
microscopy
cortexes
blood vessels
hemoglobin
stimuli
rats
high speed
activation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Srinivasan, V., Sakadžić, S., Gorczynska, I., Ruvinskaya, S., Wu, W., Fujimoto, J. G., & Boas, D. A. (2009). Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. Optics Letters, 34(20), 3086-3088. https://doi.org/10.1364/OL.34.003086

Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. / Srinivasan, Vivek; Sakadžić, Sava; Gorczynska, Iwona; Ruvinskaya, Svetlana; Wu, Weicheng; Fujimoto, James G.; Boas, David A.

In: Optics Letters, Vol. 34, No. 20, 15.10.2009, p. 3086-3088.

Research output: Contribution to journalArticle

Srinivasan, V, Sakadžić, S, Gorczynska, I, Ruvinskaya, S, Wu, W, Fujimoto, JG & Boas, DA 2009, 'Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography', Optics Letters, vol. 34, no. 20, pp. 3086-3088. https://doi.org/10.1364/OL.34.003086
Srinivasan V, Sakadžić S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG et al. Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. Optics Letters. 2009 Oct 15;34(20):3086-3088. https://doi.org/10.1364/OL.34.003086
Srinivasan, Vivek ; Sakadžić, Sava ; Gorczynska, Iwona ; Ruvinskaya, Svetlana ; Wu, Weicheng ; Fujimoto, James G. ; Boas, David A. / Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. In: Optics Letters. 2009 ; Vol. 34, No. 20. pp. 3086-3088.
@article{7e329590a92348e1924de14f3744808e,
title = "Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography",
abstract = "We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.",
author = "Vivek Srinivasan and Sava Sakadžić and Iwona Gorczynska and Svetlana Ruvinskaya and Weicheng Wu and Fujimoto, {James G.} and Boas, {David A.}",
year = "2009",
month = "10",
day = "15",
doi = "10.1364/OL.34.003086",
language = "English (US)",
volume = "34",
pages = "3086--3088",
journal = "Optics Letters",
issn = "0146-9592",
publisher = "The Optical Society",
number = "20",

}

TY - JOUR

T1 - Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

AU - Srinivasan, Vivek

AU - Sakadžić, Sava

AU - Gorczynska, Iwona

AU - Ruvinskaya, Svetlana

AU - Wu, Weicheng

AU - Fujimoto, James G.

AU - Boas, David A.

PY - 2009/10/15

Y1 - 2009/10/15

N2 - We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

AB - We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

UR - http://www.scopus.com/inward/record.url?scp=70450210232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70450210232&partnerID=8YFLogxK

U2 - 10.1364/OL.34.003086

DO - 10.1364/OL.34.003086

M3 - Article

C2 - 19838234

AN - SCOPUS:70450210232

VL - 34

SP - 3086

EP - 3088

JO - Optics Letters

JF - Optics Letters

SN - 0146-9592

IS - 20

ER -