Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

Vivek Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, David A. Boas

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

Original languageEnglish (US)
Pages (from-to)3086-3088
Number of pages3
JournalOptics Letters
Issue number20
StatePublished - Oct 15 2009
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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