Depression of cardiac function by bisantrene

M. Artman, J. S. Roloff, R. D. Olson, Mark D Parrish

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Bisantrene is a newer anthracycline derivative currently being investigated in phase 2 trials. One presumed advantage of bisantrene is that it is purportedly free of cardiotoxic effects. However, bisantrene apparently precipitated congestive heart failure after a single intravenous infusion in a young boy, prompting our study of a second child who remained asymptomatic but had transient declines in cardiac function after receiving bisantrene. Since bisantrene may acutely depress myocardial contractile function, further investigation is necessary.

Original languageEnglish (US)
Pages (from-to)1517-1518
Number of pages2
JournalSouthern Medical Journal
Issue number12
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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