Depression in type 1 diabetes and risk of dementia

Paola Gilsanz, Michal Schnaider Beeri, Andrew J. Karter, Charles P. Quesenberry, Alyce S. Adams, Rachel Whitmer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Depression afflicts 14% of individuals with type 1 diabetes (T1D). Depression is a robust risk factor for dementia but it is unknown if this holds true for individuals with T1D, who recently started living to an age conferring dementia risk. We examined if depression is a dementia risk factor among elderly individuals with T1D. Methods: 3,742 individuals with T1D age ≥50 were followed for dementia from 1/1/96-9/30/2015. Depression, dementia, and comorbidities were abstracted from electronic medical records. Cox proportional hazard models estimated the association between depression and dementia adjusting for demographics, glycosylated hemoglobin, severe dysglycemic epidsodes, stroke, heart disease, nephropathy, and end stage renal disease. The cumulative incidence of dementia by depression was estimated conditional on survival dementia-free to age 55. Results: Five percent (N = 182) were diagnosed with dementia and 20% had baseline depression. Depression was associated with a 72% increase in dementia (fully adjusted HR = 1.72; 95% CI:1.12-2.65). The 25-year cumulative incidence of dementia was more than double for those with versus without depression (27% vs. 12%). Conclusions: For people with T1D, depression significantly increases dementia risk. Given the pervasiveness of depression in T1D, this has major implications for successful aging in this population recently living to old age.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalAging and Mental Health
DOIs
StateAccepted/In press - Apr 1 2018
Externally publishedYes

Fingerprint

Type 1 Diabetes Mellitus
Dementia
Depression
Electronic Health Records
Incidence
Glycosylated Hemoglobin A
Proportional Hazards Models
Chronic Kidney Failure
Comorbidity
Heart Diseases
Stroke
Demography

Keywords

  • cohort
  • dementia
  • depression
  • Type 1 diabetes

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Gilsanz, P., Schnaider Beeri, M., Karter, A. J., Quesenberry, C. P., Adams, A. S., & Whitmer, R. (Accepted/In press). Depression in type 1 diabetes and risk of dementia. Aging and Mental Health, 1-7. https://doi.org/10.1080/13607863.2018.1455167

Depression in type 1 diabetes and risk of dementia. / Gilsanz, Paola; Schnaider Beeri, Michal; Karter, Andrew J.; Quesenberry, Charles P.; Adams, Alyce S.; Whitmer, Rachel.

In: Aging and Mental Health, 01.04.2018, p. 1-7.

Research output: Contribution to journalArticle

Gilsanz, P, Schnaider Beeri, M, Karter, AJ, Quesenberry, CP, Adams, AS & Whitmer, R 2018, 'Depression in type 1 diabetes and risk of dementia', Aging and Mental Health, pp. 1-7. https://doi.org/10.1080/13607863.2018.1455167
Gilsanz P, Schnaider Beeri M, Karter AJ, Quesenberry CP, Adams AS, Whitmer R. Depression in type 1 diabetes and risk of dementia. Aging and Mental Health. 2018 Apr 1;1-7. https://doi.org/10.1080/13607863.2018.1455167
Gilsanz, Paola ; Schnaider Beeri, Michal ; Karter, Andrew J. ; Quesenberry, Charles P. ; Adams, Alyce S. ; Whitmer, Rachel. / Depression in type 1 diabetes and risk of dementia. In: Aging and Mental Health. 2018 ; pp. 1-7.
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