Depression in stroke rehabilitation

Joseph A. Schwartz, Nancy M. Speed, James A Brunberg, Thomas L. Brewer, Morton Brown, John F. Greden

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Despite recent advances in understanding the pathophysiology of poststroke depression, major questions remain. They include the relative importance of lesion location and size and the confounding effects of time since stroke, age, prior history of depression, and cerebral atrophy. To evaluate these issues, we systematically assessed depressive features, functional status, and brain structure with computer tomography scans in 91 men undergoing stroke rehabilitation. Forty percent met DSM-III criteria for major depressive disorder. Mood disturbance was more severe for patients with right than with left hemisphere lesions, correlated with functional disability and lesion size, and was associated with previous history of depression. Age, time since stroke, and atrophy did not correlate with mood. Depression is common in delayed stroke recovery, regardless of lesion location. Because there are no demographic or anatomic features that predict the absence of depression, depression screening should be part of the assessment of all patients undergoing stroke rehabilitation.

Original languageEnglish (US)
Pages (from-to)694-699
Number of pages6
JournalBiological Psychiatry
Issue number10
StatePublished - May 15 1993
Externally publishedYes


  • CT scan
  • depression
  • organic affective disorder
  • Stroke

ASJC Scopus subject areas

  • Biological Psychiatry


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