Dependence of action potential duration on extracellular calcium concentration in a model of human ventricular myocyte

C. Pes, Eleonora Grandi, P. Avanzini, S. Severi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The mechanisms underlying the inverse relation between extracellular calcium concentration ([Ca2+]o) and action potential duration (APD) in ventricular myocytes are not fully clear. We computationally analysed the effects of [Ca2+]o variations on APD of human cardiac myocyte by means of the Ten Tusscher (2004) model. The ICaL current description was then modified in order to make the simulated results coherent with experimental findings. The original model formulation produced opposite results with respect to the expected trend, i.e. an increase of APD when increasing [Ca2+]o was observed. By strengthening the Ca2+-dependent inactivation of ICaL it was possible to reproduce the reduction of APD when increasing [Ca2+]o. The mechanism of Ca2+- dependent ICaL inactivation seems to be an high sensible pathway for APD adaptation to variations in [Ca2+]o.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology 2007, CAR 2007
Pages367-370
Number of pages4
Volume34
DOIs
StatePublished - Dec 1 2007
Externally publishedYes
EventComputers in Cardiology 2007, CAR 2007 - Durham, NC, United States
Duration: Sep 30 2007Oct 3 2007

Other

OtherComputers in Cardiology 2007, CAR 2007
CountryUnited States
CityDurham, NC
Period9/30/0710/3/07

Fingerprint

Muscle Cells
Action Potentials
Calcium
Cardiac Myocytes

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine

Cite this

Pes, C., Grandi, E., Avanzini, P., & Severi, S. (2007). Dependence of action potential duration on extracellular calcium concentration in a model of human ventricular myocyte. In Computers in Cardiology 2007, CAR 2007 (Vol. 34, pp. 367-370). [4745498] https://doi.org/10.1109/CIC.2007.4745498

Dependence of action potential duration on extracellular calcium concentration in a model of human ventricular myocyte. / Pes, C.; Grandi, Eleonora; Avanzini, P.; Severi, S.

Computers in Cardiology 2007, CAR 2007. Vol. 34 2007. p. 367-370 4745498.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pes, C, Grandi, E, Avanzini, P & Severi, S 2007, Dependence of action potential duration on extracellular calcium concentration in a model of human ventricular myocyte. in Computers in Cardiology 2007, CAR 2007. vol. 34, 4745498, pp. 367-370, Computers in Cardiology 2007, CAR 2007, Durham, NC, United States, 9/30/07. https://doi.org/10.1109/CIC.2007.4745498
Pes, C. ; Grandi, Eleonora ; Avanzini, P. ; Severi, S. / Dependence of action potential duration on extracellular calcium concentration in a model of human ventricular myocyte. Computers in Cardiology 2007, CAR 2007. Vol. 34 2007. pp. 367-370
@inproceedings{b5780ad1dd50489aa60b1b36b33e83a3,
title = "Dependence of action potential duration on extracellular calcium concentration in a model of human ventricular myocyte",
abstract = "The mechanisms underlying the inverse relation between extracellular calcium concentration ([Ca2+]o) and action potential duration (APD) in ventricular myocytes are not fully clear. We computationally analysed the effects of [Ca2+]o variations on APD of human cardiac myocyte by means of the Ten Tusscher (2004) model. The ICaL current description was then modified in order to make the simulated results coherent with experimental findings. The original model formulation produced opposite results with respect to the expected trend, i.e. an increase of APD when increasing [Ca2+]o was observed. By strengthening the Ca2+-dependent inactivation of ICaL it was possible to reproduce the reduction of APD when increasing [Ca2+]o. The mechanism of Ca2+- dependent ICaL inactivation seems to be an high sensible pathway for APD adaptation to variations in [Ca2+]o.",
author = "C. Pes and Eleonora Grandi and P. Avanzini and S. Severi",
year = "2007",
month = "12",
day = "1",
doi = "10.1109/CIC.2007.4745498",
language = "English (US)",
isbn = "9781424425334",
volume = "34",
pages = "367--370",
booktitle = "Computers in Cardiology 2007, CAR 2007",

}

TY - GEN

T1 - Dependence of action potential duration on extracellular calcium concentration in a model of human ventricular myocyte

AU - Pes, C.

AU - Grandi, Eleonora

AU - Avanzini, P.

AU - Severi, S.

PY - 2007/12/1

Y1 - 2007/12/1

N2 - The mechanisms underlying the inverse relation between extracellular calcium concentration ([Ca2+]o) and action potential duration (APD) in ventricular myocytes are not fully clear. We computationally analysed the effects of [Ca2+]o variations on APD of human cardiac myocyte by means of the Ten Tusscher (2004) model. The ICaL current description was then modified in order to make the simulated results coherent with experimental findings. The original model formulation produced opposite results with respect to the expected trend, i.e. an increase of APD when increasing [Ca2+]o was observed. By strengthening the Ca2+-dependent inactivation of ICaL it was possible to reproduce the reduction of APD when increasing [Ca2+]o. The mechanism of Ca2+- dependent ICaL inactivation seems to be an high sensible pathway for APD adaptation to variations in [Ca2+]o.

AB - The mechanisms underlying the inverse relation between extracellular calcium concentration ([Ca2+]o) and action potential duration (APD) in ventricular myocytes are not fully clear. We computationally analysed the effects of [Ca2+]o variations on APD of human cardiac myocyte by means of the Ten Tusscher (2004) model. The ICaL current description was then modified in order to make the simulated results coherent with experimental findings. The original model formulation produced opposite results with respect to the expected trend, i.e. an increase of APD when increasing [Ca2+]o was observed. By strengthening the Ca2+-dependent inactivation of ICaL it was possible to reproduce the reduction of APD when increasing [Ca2+]o. The mechanism of Ca2+- dependent ICaL inactivation seems to be an high sensible pathway for APD adaptation to variations in [Ca2+]o.

UR - http://www.scopus.com/inward/record.url?scp=62949199908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62949199908&partnerID=8YFLogxK

U2 - 10.1109/CIC.2007.4745498

DO - 10.1109/CIC.2007.4745498

M3 - Conference contribution

AN - SCOPUS:62949199908

SN - 9781424425334

VL - 34

SP - 367

EP - 370

BT - Computers in Cardiology 2007, CAR 2007

ER -