Dense deposit disease and the factor H H402 allele

Keith K. Lau, Richard J. Smith, Peter C. Kolbeck, Lavjay Butani

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Herein, we describe the case of an 8-year-old boy who presented with a nephritic nephrotic syndrome. His laboratory investigation was significant for a persistently low serum complement 3 level. A renal biopsy was performed, based on which, he was diagnosed with dense deposit disease/membranoproliferative glomerulonephritis type II (DDD/MPGN II). He was treated with alternate-day oral corticosteroids, angiotensin-converting enzyme (ACE) inhibitors and tacrolimus. Factor H mutational analysis showed the Y402H and I62V allele polymorphisms. The purpose of our report is to discuss the association of the H402 allele variant of factor H with the DDD/MPGN II phenotype and its possible therapeutic implications.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalClinical and Experimental Nephrology
Issue number3
StatePublished - Jun 2008


  • C3 nephritic factor
  • Dense deposit disease
  • Factor H
  • MPGN

ASJC Scopus subject areas

  • Nephrology


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