Abstract
Herein, we describe the case of an 8-year-old boy who presented with a nephritic nephrotic syndrome. His laboratory investigation was significant for a persistently low serum complement 3 level. A renal biopsy was performed, based on which, he was diagnosed with dense deposit disease/membranoproliferative glomerulonephritis type II (DDD/MPGN II). He was treated with alternate-day oral corticosteroids, angiotensin-converting enzyme (ACE) inhibitors and tacrolimus. Factor H mutational analysis showed the Y402H and I62V allele polymorphisms. The purpose of our report is to discuss the association of the H402 allele variant of factor H with the DDD/MPGN II phenotype and its possible therapeutic implications.
Original language | English (US) |
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Pages (from-to) | 228-232 |
Number of pages | 5 |
Journal | Clinical and Experimental Nephrology |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2008 |
Keywords
- C3 nephritic factor
- Dense deposit disease
- Factor H
- MPGN
ASJC Scopus subject areas
- Nephrology