Dendrites of rod bipolar cells sprout in normal aging retina

Lauren C. Liets, Kasra Eliasieh, Deborah A. Van Der List, Leo M. Chalupa

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

The aging nervous system is known to manifest a variety of degenerative and regressive events. Here we report the unexpected growth of dendrites in the retinas of normal old mice. The dendrites of many rod bipolar cells in aging mice were observed to extend well beyond their normal strata within the outer plexiform layer to innervate the outer nuclear layer where they appeared to form contacts with the spherules of rod photoreceptors. Such dendritic sprouting increased with age and was evident at all retinal eccentricities. These results provide evidence of retinal plasticity associated with normal aging.

Original languageEnglish (US)
Pages (from-to)12156-12160
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number32
DOIs
StatePublished - Aug 8 2006

Keywords

  • Plasticity
  • Senescence
  • Visual system

ASJC Scopus subject areas

  • General

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