Demonstration of a tubular basement membrane antibody in the pathogenesis of autoimmune nephrosis in rats

Sudesh P Makker, W. Heymann

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Another humoral autoantibody tubular basement membrane antibody (TBMAb) has been demonstrated in the immune sera of Lewis rats in whom autoimmune nephrosis was produced by repeated intraperitoneal injections of a mixture containing complete Freund's adjuvant and a kidney tubular fraction obtained from normal Sprague Dawley rats. The antibody, by indirect immunofluorescent technique, localized in a linear pattern along the normal tubular basement membrane and Bowman's capsule, but not along the glomerular basement membrane. Also the antibody (TBMAb) could be eluted from the immune deposits in the glomeruli of the diseased animals. These studies suggest the nephritogenicity of this antibody (TBMAb) and point out that at least two antigens (BBAg and TBMAg) may by nephritogenic in this form of experimental autoimmune nephrosis.

Original languageEnglish (US)
Pages (from-to)995-999
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume143
Issue number4
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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