Demographics, presentation, and diagnosis

Francisco Vaz-Guimaraes, Griffith R. Harsh

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Chordomas and chondrosarcomas are rare bone cancers that share many clinicoradiological similarities. Nevertheless, they are distinct pathological entities that markedly differ regarding their origin, history, and prognosis. Chordomas represent 3% of primary bone tumors, develop from remnants of the primitive notochord, and may affect the skull base and any part of the spine. Chondrosarcomas represent 7% of primary bone tumors, appear to develop from cartilaginous rests during the process of ossification, and most commonly involve the long bones of the appendicular skeleton, although they may also affect the axial skeleton. Given the importance of distinguishing between these neoplasms for proper management, this chapter will review demographic and clinical data emphasizing their differences.

Original languageEnglish (US)
Title of host publicationChordomas and Chondrosarcomas of the Skull Base and Spine
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780128043332
ISBN (Print)9780128042571
StatePublished - 2018
Externally publishedYes


  • Chondrosarcoma
  • Chordoma
  • Clinical presentation
  • Demographics
  • Diagnosis

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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