Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum

Todd A. Jusko, Marina Oktapodas, L'Ubica Palkovičová Murinová, Katarina Babinská, Jana Babjaková, Marc André Verner, Jamie C. Dewitt, Kelly Thevenet-Morrison, Kamil Čonka, Beata Drobná, Jana Chovancová, Sally W. Thurston, B. Paige Lawrence, Ann M. Dozier, Kirsi M. Järvinen, Henrieta Patayová, Tomáš Trnovec, Juliette Legler, Irva Hertz-Picciotto, Marja H. Lamoree

Research output: Contribution to journalArticle

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Abstract

To determine demographic, reproductive, and maternal dietary factors that predict perfluoroalkyl substance (PFAS) concentrations in breast milk, we measured perfluorooctane sulfonic (PFOS) and perfluorooctanoic acid (PFOA) concentrations, using liquid chromatography-mass spectrometry, in 184 colostrum samples collected from women participating in a cohort study in Eastern Slovakia between 2002 and 2004. During their hospital delivery stay, mothers completed a food frequency questionnaire, and demographic and reproductive data were also collected. PFOS and PFOA predictors were identified by optimizing multiple linear regression models using Akaike's information criterion (AIC). The geometric mean concentration in colostrum was 35.3 pg/mL for PFOS and 32.8 pg/mL for PFOA. In multivariable models, parous women had 40% lower PFOS (95% CI: -56 to -17%) and 40% lower PFOA (95% CI: -54 to -23%) concentrations compared with nulliparous women. Moreover, fresh/frozen fish consumption, longer birth intervals, and Slovak ethnicity were associated with higher PFOS and PFOA concentrations in colostrum. These results will help guide the design of future epidemiologic studies examining milk PFAS concentrations in relation to health end points in children.

Original languageEnglish (US)
Pages (from-to)7152-7162
Number of pages11
JournalEnvironmental Science and Technology
Volume50
Issue number13
DOIs
StatePublished - Jul 5 2016

Fingerprint

perfluorooctanoic acid
acid
birth interval
Akaike information criterion
Liquid chromatography
ethnicity
Linear regression
Fish
milk
Mass spectrometry
liquid chromatography
mass spectrometry
perfluorooctane sulfonic acid
Health

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Jusko, T. A., Oktapodas, M., Palkovičová Murinová, LU., Babinská, K., Babjaková, J., Verner, M. A., ... Lamoree, M. H. (2016). Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum. Environmental Science and Technology, 50(13), 7152-7162. https://doi.org/10.1021/acs.est.6b00195

Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum. / Jusko, Todd A.; Oktapodas, Marina; Palkovičová Murinová, L'Ubica; Babinská, Katarina; Babjaková, Jana; Verner, Marc André; Dewitt, Jamie C.; Thevenet-Morrison, Kelly; Čonka, Kamil; Drobná, Beata; Chovancová, Jana; Thurston, Sally W.; Lawrence, B. Paige; Dozier, Ann M.; Järvinen, Kirsi M.; Patayová, Henrieta; Trnovec, Tomáš; Legler, Juliette; Hertz-Picciotto, Irva; Lamoree, Marja H.

In: Environmental Science and Technology, Vol. 50, No. 13, 05.07.2016, p. 7152-7162.

Research output: Contribution to journalArticle

Jusko, TA, Oktapodas, M, Palkovičová Murinová, LU, Babinská, K, Babjaková, J, Verner, MA, Dewitt, JC, Thevenet-Morrison, K, Čonka, K, Drobná, B, Chovancová, J, Thurston, SW, Lawrence, BP, Dozier, AM, Järvinen, KM, Patayová, H, Trnovec, T, Legler, J, Hertz-Picciotto, I & Lamoree, MH 2016, 'Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum', Environmental Science and Technology, vol. 50, no. 13, pp. 7152-7162. https://doi.org/10.1021/acs.est.6b00195
Jusko, Todd A. ; Oktapodas, Marina ; Palkovičová Murinová, L'Ubica ; Babinská, Katarina ; Babjaková, Jana ; Verner, Marc André ; Dewitt, Jamie C. ; Thevenet-Morrison, Kelly ; Čonka, Kamil ; Drobná, Beata ; Chovancová, Jana ; Thurston, Sally W. ; Lawrence, B. Paige ; Dozier, Ann M. ; Järvinen, Kirsi M. ; Patayová, Henrieta ; Trnovec, Tomáš ; Legler, Juliette ; Hertz-Picciotto, Irva ; Lamoree, Marja H. / Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum. In: Environmental Science and Technology. 2016 ; Vol. 50, No. 13. pp. 7152-7162.
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T1 - Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum

AU - Jusko, Todd A.

AU - Oktapodas, Marina

AU - Palkovičová Murinová, L'Ubica

AU - Babinská, Katarina

AU - Babjaková, Jana

AU - Verner, Marc André

AU - Dewitt, Jamie C.

AU - Thevenet-Morrison, Kelly

AU - Čonka, Kamil

AU - Drobná, Beata

AU - Chovancová, Jana

AU - Thurston, Sally W.

AU - Lawrence, B. Paige

AU - Dozier, Ann M.

AU - Järvinen, Kirsi M.

AU - Patayová, Henrieta

AU - Trnovec, Tomáš

AU - Legler, Juliette

AU - Hertz-Picciotto, Irva

AU - Lamoree, Marja H.

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