Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques

Ryan D. Hernandez, Melissa J. Hubisz, David A. Wheeler, David G. Smith, Betsy Ferguson, Jeffrey Rogers, Lynne Nazareth, Amit Indap, Traci Bourquin, John Douglas Mcpherson, Donna Muzny, Richard Gibbs, Rasmus Nielsen, Carlos D. Bustamante

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121 Scopus citations

Abstract

To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r2 ≈ 0.15 at 10 kilobases) versus Indian (r2 ≈ 0.52 at 10 kilobases) macaque populations.

Original languageEnglish (US)
Pages (from-to)240-243
Number of pages4
JournalScience
Volume316
Issue number5822
DOIs
StatePublished - Apr 13 2007
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • General

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    Hernandez, R. D., Hubisz, M. J., Wheeler, D. A., Smith, D. G., Ferguson, B., Rogers, J., Nazareth, L., Indap, A., Bourquin, T., Mcpherson, J. D., Muzny, D., Gibbs, R., Nielsen, R., & Bustamante, C. D. (2007). Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques. Science, 316(5822), 240-243. https://doi.org/10.1126/science.1140462