Abstract
Morphogenesis is the developmental cascade of pattern formation, body-plan establishment and interpretation and differentiation of the pattern. Morphogenesis is induced by morphogens. Morphogens are generally first identified in fly and frog embryos by genetic approaches, differential displays, subtractive hybridization and expression cloning, and this information is then extended to mice and men. This chapter demonstrates an alternative biochemical approach based on regenerative potential of adult mammalian demineralized bone matrix (DBM). Decalcified extracellular bone matrix has been used to treat patients with osteomyelitis. Chemotaxis is the directed migration of cells in response to chemical gradient of signals released from the insoluble demineralized bone matrix. The demineralized bone matrix-induced bone morphogenesis in extraskeletal sites demonstrated the possible presence of morphogens in the extracellular matrix of bone. Bone morphogenetic protein (BMPs) is dimeric molecules and the conformation is critical for biological actions.
| Original language | English (US) |
|---|---|
| Title of host publication | Biomaterials from Nature for Advanced Devices and Therapies |
| Publisher | Wiley Blackwell |
| Pages | 211-219 |
| Number of pages | 9 |
| ISBN (Electronic) | 9781119126218 |
| ISBN (Print) | 9781118478059 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- Bone morphogenetic protein
- Chemotaxis
- Demineralized bone matrix
- Expression cloning
- Genetic approaches
- Morphogenesis
- Morphogenetic extracellular matrix
- Osteomyelitis
- Subtractive hybridization
ASJC Scopus subject areas
- Engineering(all)
- Materials Science(all)
Cite this
Demineralized Bone Matrix : A Morphogenetic Extracellular Matrix. / Reddi, A Hari; Sakata, Ryosuke.
Biomaterials from Nature for Advanced Devices and Therapies. Wiley Blackwell, 2016. p. 211-219.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Demineralized Bone Matrix
T2 - A Morphogenetic Extracellular Matrix
AU - Reddi, A Hari
AU - Sakata, Ryosuke
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Morphogenesis is the developmental cascade of pattern formation, body-plan establishment and interpretation and differentiation of the pattern. Morphogenesis is induced by morphogens. Morphogens are generally first identified in fly and frog embryos by genetic approaches, differential displays, subtractive hybridization and expression cloning, and this information is then extended to mice and men. This chapter demonstrates an alternative biochemical approach based on regenerative potential of adult mammalian demineralized bone matrix (DBM). Decalcified extracellular bone matrix has been used to treat patients with osteomyelitis. Chemotaxis is the directed migration of cells in response to chemical gradient of signals released from the insoluble demineralized bone matrix. The demineralized bone matrix-induced bone morphogenesis in extraskeletal sites demonstrated the possible presence of morphogens in the extracellular matrix of bone. Bone morphogenetic protein (BMPs) is dimeric molecules and the conformation is critical for biological actions.
AB - Morphogenesis is the developmental cascade of pattern formation, body-plan establishment and interpretation and differentiation of the pattern. Morphogenesis is induced by morphogens. Morphogens are generally first identified in fly and frog embryos by genetic approaches, differential displays, subtractive hybridization and expression cloning, and this information is then extended to mice and men. This chapter demonstrates an alternative biochemical approach based on regenerative potential of adult mammalian demineralized bone matrix (DBM). Decalcified extracellular bone matrix has been used to treat patients with osteomyelitis. Chemotaxis is the directed migration of cells in response to chemical gradient of signals released from the insoluble demineralized bone matrix. The demineralized bone matrix-induced bone morphogenesis in extraskeletal sites demonstrated the possible presence of morphogens in the extracellular matrix of bone. Bone morphogenetic protein (BMPs) is dimeric molecules and the conformation is critical for biological actions.
KW - Bone morphogenetic protein
KW - Chemotaxis
KW - Demineralized bone matrix
KW - Expression cloning
KW - Genetic approaches
KW - Morphogenesis
KW - Morphogenetic extracellular matrix
KW - Osteomyelitis
KW - Subtractive hybridization
UR - http://www.scopus.com/inward/record.url?scp=85019860888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019860888&partnerID=8YFLogxK
U2 - 10.1002/9781119126218.ch13
DO - 10.1002/9781119126218.ch13
M3 - Chapter
SN - 9781118478059
SP - 211
EP - 219
BT - Biomaterials from Nature for Advanced Devices and Therapies
PB - Wiley Blackwell
ER -