Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: Clinical intervention with donepezil and venlafaxine

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Abstract

The authors present a case of a patient with dementia with mood symptoms and multiple neurological manifestations of fragile X-associated tremor/ataxia syndrome (FXTAS). Despite a gradually deteriorating neurological course, he was managed for 2 years with combination therapy of donepezil and venlafaxine, which resulted in improvement and relative stabilization of his psychiatric status. Psychiatrists are hereby alerted to the description of a novel dementia syndrome that may respond to pharmacological intervention commonly used for other dementias.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume18
Issue number2
DOIs
StatePublished - Mar 2006

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Dementia
Psychiatry
Neurologic Manifestations
Pharmacology
donepezil
Fragile X Tremor Ataxia Syndrome
Venlafaxine Hydrochloride
Therapeutics

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

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abstract = "The authors present a case of a patient with dementia with mood symptoms and multiple neurological manifestations of fragile X-associated tremor/ataxia syndrome (FXTAS). Despite a gradually deteriorating neurological course, he was managed for 2 years with combination therapy of donepezil and venlafaxine, which resulted in improvement and relative stabilization of his psychiatric status. Psychiatrists are hereby alerted to the description of a novel dementia syndrome that may respond to pharmacological intervention commonly used for other dementias.",
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AU - Zhang, Lin

AU - Hessl, David

AU - Hagerman, Randi

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