Dementia and cognitive decline in type 2 diabetes and prediabetic stages: Towards targeted interventions

Geert Jan Biessels, Mark W.J. Strachan, Frank L.J. Visseren, L. Jaap Kappelle, Rachel Whitmer

Research output: Contribution to journalReview article

196 Citations (Scopus)

Abstract

Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements. In this Review we discuss trajectories from normal cognition to dementia in people with type 2 diabetes, and explore opportunities for treatment. Slight diabetes-associated cognitive decrements and dementia affect different age groups and show a different evolution. These cognitive entities should therefore not be regarded as a continuum, although their effects might be additive. Vascular damage is a key underlying process in both entities. Glucose-mediated processes and other metabolic disturbances might also have a role. No treatment has been established, but management of vascular risk factors and optimisation of glycaemic control could have therapeutic benefit. We identify possible opportunities for intervention to improve cognitive outcomes in people with type 2 diabetes, and suggest how treatment can be tailored to individual risk profiles and comorbidities.

Original languageEnglish (US)
Pages (from-to)246-255
Number of pages10
JournalThe Lancet Diabetes and Endocrinology
Volume2
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Dementia
Therapeutics
Cognition
Blood Vessels
Comorbidity
Age Groups
Glucose
Cognitive Dysfunction

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Dementia and cognitive decline in type 2 diabetes and prediabetic stages : Towards targeted interventions. / Biessels, Geert Jan; Strachan, Mark W.J.; Visseren, Frank L.J.; Kappelle, L. Jaap; Whitmer, Rachel.

In: The Lancet Diabetes and Endocrinology, Vol. 2, No. 3, 01.01.2014, p. 246-255.

Research output: Contribution to journalReview article

Biessels, Geert Jan ; Strachan, Mark W.J. ; Visseren, Frank L.J. ; Kappelle, L. Jaap ; Whitmer, Rachel. / Dementia and cognitive decline in type 2 diabetes and prediabetic stages : Towards targeted interventions. In: The Lancet Diabetes and Endocrinology. 2014 ; Vol. 2, No. 3. pp. 246-255.
@article{52dfea00dc6d48d98e964d1c961c99af,
title = "Dementia and cognitive decline in type 2 diabetes and prediabetic stages: Towards targeted interventions",
abstract = "Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements. In this Review we discuss trajectories from normal cognition to dementia in people with type 2 diabetes, and explore opportunities for treatment. Slight diabetes-associated cognitive decrements and dementia affect different age groups and show a different evolution. These cognitive entities should therefore not be regarded as a continuum, although their effects might be additive. Vascular damage is a key underlying process in both entities. Glucose-mediated processes and other metabolic disturbances might also have a role. No treatment has been established, but management of vascular risk factors and optimisation of glycaemic control could have therapeutic benefit. We identify possible opportunities for intervention to improve cognitive outcomes in people with type 2 diabetes, and suggest how treatment can be tailored to individual risk profiles and comorbidities.",
author = "Biessels, {Geert Jan} and Strachan, {Mark W.J.} and Visseren, {Frank L.J.} and Kappelle, {L. Jaap} and Rachel Whitmer",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/S2213-8587(13)70088-3",
language = "English (US)",
volume = "2",
pages = "246--255",
journal = "The Lancet Diabetes and Endocrinology",
issn = "2213-8587",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Dementia and cognitive decline in type 2 diabetes and prediabetic stages

T2 - Towards targeted interventions

AU - Biessels, Geert Jan

AU - Strachan, Mark W.J.

AU - Visseren, Frank L.J.

AU - Kappelle, L. Jaap

AU - Whitmer, Rachel

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements. In this Review we discuss trajectories from normal cognition to dementia in people with type 2 diabetes, and explore opportunities for treatment. Slight diabetes-associated cognitive decrements and dementia affect different age groups and show a different evolution. These cognitive entities should therefore not be regarded as a continuum, although their effects might be additive. Vascular damage is a key underlying process in both entities. Glucose-mediated processes and other metabolic disturbances might also have a role. No treatment has been established, but management of vascular risk factors and optimisation of glycaemic control could have therapeutic benefit. We identify possible opportunities for intervention to improve cognitive outcomes in people with type 2 diabetes, and suggest how treatment can be tailored to individual risk profiles and comorbidities.

AB - Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements. In this Review we discuss trajectories from normal cognition to dementia in people with type 2 diabetes, and explore opportunities for treatment. Slight diabetes-associated cognitive decrements and dementia affect different age groups and show a different evolution. These cognitive entities should therefore not be regarded as a continuum, although their effects might be additive. Vascular damage is a key underlying process in both entities. Glucose-mediated processes and other metabolic disturbances might also have a role. No treatment has been established, but management of vascular risk factors and optimisation of glycaemic control could have therapeutic benefit. We identify possible opportunities for intervention to improve cognitive outcomes in people with type 2 diabetes, and suggest how treatment can be tailored to individual risk profiles and comorbidities.

UR - http://www.scopus.com/inward/record.url?scp=84895463355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895463355&partnerID=8YFLogxK

U2 - 10.1016/S2213-8587(13)70088-3

DO - 10.1016/S2213-8587(13)70088-3

M3 - Review article

C2 - 24622755

AN - SCOPUS:84895463355

VL - 2

SP - 246

EP - 255

JO - The Lancet Diabetes and Endocrinology

JF - The Lancet Diabetes and Endocrinology

SN - 2213-8587

IS - 3

ER -