Delipidated retroviruses as potential autologous therapeutic vaccines - A pilot experiment

Moiz Kltabwalla, Aftab A. Ansari, Francois Vlllinger, Hassibullah Akeefe, Adam P. Conner, Ann E. Mayne, James Hildreth

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

This pilot experiment in a simian immunodeficiency virus (SIV) chronic infection model aimed at extending our previous findings that vaccination with delipidated SIV resulted in more potent and diversified antiviral responses (1). Macaques chronically infected with SIVmac239 treated with antiretroviral therapy (ART) were vaccinated with autologous delipidated virus via consecutive lymph node targeted immunizations-1,1 and 10 ig of virus spaced monthly. Results showed all animals had lasting viral load reduction approaching 1 log compared to set-point, and disease delay. Delipidation may enhance processing/ presentation of viral antigen eliciting potent antiviral control even at such late infection stage.

Original languageEnglish (US)
Pages (from-to)732-740
Number of pages9
JournalExperimental Biology and Medicine
Volume233
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Keywords

  • Delipidation
  • SIV
  • Therapeutic vaccination

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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