Abstract
To evaluate the use of high-resolution magnetic resonance imaging (MRI) for the differentiation of skin tumors in the maxillofacial region, 60 patients (25 female) were examined in a 1.5-T whole-body MR imager with a 2.5-cm surface coil. Plain transverse T1- (TR 500 ms, TE 25 ms), T2- (2200 ms, TE 80 ms), fat(TR 500 ms, TE 28 ms), and water-suppressed (TR 500 ms, TE 38 ms) SE sequences were used. Following the application of the paramagnetic contrast agent Gd-DTPA, transverse T1-weighted and fat suppression sequences were repeated. Before and after contrast administration, tumor signal intensities and percent contrast enhancement were determined by a ROI technique. All tumors were classified by standard histologic technique and evaluated with regard to their response to contrast medium. Quantitative evaluation was performed by three independent radiologists. Additionally, signal- and contrast-to-noise ratios were calculated for each tumor type. All MRI findings were compared with histology. Significant contrast enhancement occurred in most tumors; malignant tumors displayed inhomogeneous enhancement. The optimal pulse sequences for tumor delineation are plain T1-weighted, water-suppressed, and contrast-enhanced fat-suppressed sequences. Tumors could not be specified by signal intensities or percent contrast enhancement, and CNR did not allow for malignant lesions to be differentiated from benign tumors. High-resolution MRI proved to be an adequate method for imaging skin tumors and their inner structure. Tumor typing was not possible by either contrast-administration or modification of sequence parameters. In this regard, further innovations in contrast agent design seem to be necessary.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 540-543 |
| Number of pages | 4 |
| Journal | Cancer Detection and Prevention |
| Volume | 22 |
| Issue number | 6 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Contrast medium
- High resolution technique
- Magnetic resonance imaging
- Skin tumors
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Delineation of maxillofacial cutaneous lesions by means of high-resolution magnetic resonance imaging. / Maurer, J.; Knollmann, Friedrich D; Hell, B.; Radke, C.; Felix, R.
In: Cancer Detection and Prevention, Vol. 22, No. 6, 1998, p. 540-543.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Delineation of maxillofacial cutaneous lesions by means of high-resolution magnetic resonance imaging
AU - Maurer, J.
AU - Knollmann, Friedrich D
AU - Hell, B.
AU - Radke, C.
AU - Felix, R.
PY - 1998
Y1 - 1998
N2 - To evaluate the use of high-resolution magnetic resonance imaging (MRI) for the differentiation of skin tumors in the maxillofacial region, 60 patients (25 female) were examined in a 1.5-T whole-body MR imager with a 2.5-cm surface coil. Plain transverse T1- (TR 500 ms, TE 25 ms), T2- (2200 ms, TE 80 ms), fat(TR 500 ms, TE 28 ms), and water-suppressed (TR 500 ms, TE 38 ms) SE sequences were used. Following the application of the paramagnetic contrast agent Gd-DTPA, transverse T1-weighted and fat suppression sequences were repeated. Before and after contrast administration, tumor signal intensities and percent contrast enhancement were determined by a ROI technique. All tumors were classified by standard histologic technique and evaluated with regard to their response to contrast medium. Quantitative evaluation was performed by three independent radiologists. Additionally, signal- and contrast-to-noise ratios were calculated for each tumor type. All MRI findings were compared with histology. Significant contrast enhancement occurred in most tumors; malignant tumors displayed inhomogeneous enhancement. The optimal pulse sequences for tumor delineation are plain T1-weighted, water-suppressed, and contrast-enhanced fat-suppressed sequences. Tumors could not be specified by signal intensities or percent contrast enhancement, and CNR did not allow for malignant lesions to be differentiated from benign tumors. High-resolution MRI proved to be an adequate method for imaging skin tumors and their inner structure. Tumor typing was not possible by either contrast-administration or modification of sequence parameters. In this regard, further innovations in contrast agent design seem to be necessary.
AB - To evaluate the use of high-resolution magnetic resonance imaging (MRI) for the differentiation of skin tumors in the maxillofacial region, 60 patients (25 female) were examined in a 1.5-T whole-body MR imager with a 2.5-cm surface coil. Plain transverse T1- (TR 500 ms, TE 25 ms), T2- (2200 ms, TE 80 ms), fat(TR 500 ms, TE 28 ms), and water-suppressed (TR 500 ms, TE 38 ms) SE sequences were used. Following the application of the paramagnetic contrast agent Gd-DTPA, transverse T1-weighted and fat suppression sequences were repeated. Before and after contrast administration, tumor signal intensities and percent contrast enhancement were determined by a ROI technique. All tumors were classified by standard histologic technique and evaluated with regard to their response to contrast medium. Quantitative evaluation was performed by three independent radiologists. Additionally, signal- and contrast-to-noise ratios were calculated for each tumor type. All MRI findings were compared with histology. Significant contrast enhancement occurred in most tumors; malignant tumors displayed inhomogeneous enhancement. The optimal pulse sequences for tumor delineation are plain T1-weighted, water-suppressed, and contrast-enhanced fat-suppressed sequences. Tumors could not be specified by signal intensities or percent contrast enhancement, and CNR did not allow for malignant lesions to be differentiated from benign tumors. High-resolution MRI proved to be an adequate method for imaging skin tumors and their inner structure. Tumor typing was not possible by either contrast-administration or modification of sequence parameters. In this regard, further innovations in contrast agent design seem to be necessary.
KW - Contrast medium
KW - High resolution technique
KW - Magnetic resonance imaging
KW - Skin tumors
UR - http://www.scopus.com/inward/record.url?scp=0031732792&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031732792&partnerID=8YFLogxK
M3 - Article
C2 - 9824377
AN - SCOPUS:0031732792
VL - 22
SP - 540
EP - 543
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
IS - 6
ER -