Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway

Hiroshi Ozawa, Seiji Shioda, Kenji Dohi, Hiroaki Matsumoto, Hidekatsu Mizushima, Chengji Zhou, Hisayuki Funahashi, Yasumitsu Nakai, Shigeo Nakajo, Kiyoshi Matsumoto

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

Transient global ischemia caused by 5 min of cardiac arrest induced delayed neuronal cell death (apoptosis) in the CA1 region of the rat hippocampus. To characterize the molecular mechanisms that regulate apoptosis in vivo, the contributions to cell death of mitogen-activated protein kinase family members were examined in the hippocampal region after brain ischemia- reperfusion. Ischemia-reperfusion led to a strong activation of the JNK/SAPK (c-Jun NH2-terminal protein kinase/stress activated protein kinase), ERK (extracellular signal-regulated kinase), and p38 enzymes. These results with other previous studies suggest that the activation of JNK/SAPK in accordance with p38 contributes to the induction of apoptosis in CA1 neurons.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume262
Issue number1
DOIs
StatePublished - Feb 19 1999
Externally publishedYes

Keywords

  • Apoptosis
  • Hippocampal pyramidal cells
  • Ischemia
  • Mitogen-activated protein kinases
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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    Ozawa, H., Shioda, S., Dohi, K., Matsumoto, H., Mizushima, H., Zhou, C., Funahashi, H., Nakai, Y., Nakajo, S., & Matsumoto, K. (1999). Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway. Neuroscience Letters, 262(1), 57-60. https://doi.org/10.1016/S0304-3940(99)00034-8