Delay period activity of the substantia nigra during proactive control of response selection as determined by a novel fMRI localization method

Jong H. Yoon, Paul Larson, Anthony Grandelis, Christian La, Edward Cui, Cameron S Carter, Michael J. Minzenberg

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The ability to proactively control motor responses, particularly to overcome overlearned or automatic actions, is an essential prerequisite for adaptive, goal-oriented behavior. The substantia nigra (SN), an element of the BG, has figured prominently in current models of response selection. However, because of its small size and proximity to functionally distinct subcortical structures, it has been challenging to test the SN’s involvement in response selection using conventional in vivo functional neuroimaging approaches. We developed a new fMRI localization method for directly distinguishing, on echo-planar images, the SN BOLD signal from that of neighboring structures, including the subthalamic nucleus (STN). Using this method, we tested the hypothesis that the SN supports the proactive control of response selection. We acquired high-resolution EPI volumes at 3 T from 16 healthy participants while they completed the Preparing to Overcome Prepotency task of proactive control. There was significantly elevated delay period signal selectively during high- compared with low-control trials in the SN. The STN did not show delay period activity in either condition. SN delay period signal was significantly inversely associated with task performance RTs across participants. These results suggest that our method offers a novel means for measuring SN BOLD responses, provides unique evidence of SN involvement in cognitive control in humans, and suggests a novel mechanism for proactive response selection.

Original languageEnglish (US)
Pages (from-to)1238-1248
Number of pages11
JournalJournal of Cognitive Neuroscience
Volume27
Issue number6
DOIs
StatePublished - Jun 5 2015

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Substantia Nigra
Magnetic Resonance Imaging
Subthalamic Nucleus
Functional Neuroimaging
Aptitude
Task Performance and Analysis
Localization
Functional Magnetic Resonance Imaging
Healthy Volunteers
ability
performance
evidence

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Language and Linguistics
  • Linguistics and Language

Cite this

Delay period activity of the substantia nigra during proactive control of response selection as determined by a novel fMRI localization method. / Yoon, Jong H.; Larson, Paul; Grandelis, Anthony; La, Christian; Cui, Edward; Carter, Cameron S; Minzenberg, Michael J.

In: Journal of Cognitive Neuroscience, Vol. 27, No. 6, 05.06.2015, p. 1238-1248.

Research output: Contribution to journalArticle

Yoon, Jong H. ; Larson, Paul ; Grandelis, Anthony ; La, Christian ; Cui, Edward ; Carter, Cameron S ; Minzenberg, Michael J. / Delay period activity of the substantia nigra during proactive control of response selection as determined by a novel fMRI localization method. In: Journal of Cognitive Neuroscience. 2015 ; Vol. 27, No. 6. pp. 1238-1248.
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