Abstract
Delay discounting (DD) is the phenomenon of individuals discounting future rewards as a function of time. It has been studied extensively in chronic schizophrenia (SZ) and the results of these studies have been variable. Comorbidity in chronic samples could be one reason for the mixed findings and studies in first-episode (FE) samples are surprisingly lacking. Bipolar disorder (BP) which shares some genetic and symptom features with SZ could serve as an interesting comparison group for DD but has been underexplored. Here we present the first study that combines FE SZ, FE BP with psychotic features, as well as healthy controls and study DD with two versions of the task. We found that SZ showed steeper discounting than HC and BP on the well-validated Kirby DD task. SZ showed no difference than HC on a separate DD task with smaller rewards presented with decimal places and shorter delays. As a preliminary finding, DD was found to be positively related to positive symptoms in FE SZ, while no relationship was found between negative symptoms and DD. In addition, we found comparable DD in BP compared to HC. Ultimately, our data may help elucidate the psychopathology in SZ and BP during intertemporal decision making.
| Original language | English (US) |
|---|---|
| Journal | Schizophrenia Research |
| DOIs | |
| State | Accepted/In press - Jan 1 2020 |
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Keywords
- Delay discounting
- First-episode bipolar disorder
- First-episode schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Delay discounting abnormalities are seen in first-episode schizophrenia but not in bipolar disorder. / Wang, Huan; Lesh, Tyler A.; Maddock, Richard J.; Fassbender, Catherine; Carter, Cameron S.
In: Schizophrenia Research, 01.01.2020.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Delay discounting abnormalities are seen in first-episode schizophrenia but not in bipolar disorder
AU - Wang, Huan
AU - Lesh, Tyler A.
AU - Maddock, Richard J.
AU - Fassbender, Catherine
AU - Carter, Cameron S.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Delay discounting (DD) is the phenomenon of individuals discounting future rewards as a function of time. It has been studied extensively in chronic schizophrenia (SZ) and the results of these studies have been variable. Comorbidity in chronic samples could be one reason for the mixed findings and studies in first-episode (FE) samples are surprisingly lacking. Bipolar disorder (BP) which shares some genetic and symptom features with SZ could serve as an interesting comparison group for DD but has been underexplored. Here we present the first study that combines FE SZ, FE BP with psychotic features, as well as healthy controls and study DD with two versions of the task. We found that SZ showed steeper discounting than HC and BP on the well-validated Kirby DD task. SZ showed no difference than HC on a separate DD task with smaller rewards presented with decimal places and shorter delays. As a preliminary finding, DD was found to be positively related to positive symptoms in FE SZ, while no relationship was found between negative symptoms and DD. In addition, we found comparable DD in BP compared to HC. Ultimately, our data may help elucidate the psychopathology in SZ and BP during intertemporal decision making.
AB - Delay discounting (DD) is the phenomenon of individuals discounting future rewards as a function of time. It has been studied extensively in chronic schizophrenia (SZ) and the results of these studies have been variable. Comorbidity in chronic samples could be one reason for the mixed findings and studies in first-episode (FE) samples are surprisingly lacking. Bipolar disorder (BP) which shares some genetic and symptom features with SZ could serve as an interesting comparison group for DD but has been underexplored. Here we present the first study that combines FE SZ, FE BP with psychotic features, as well as healthy controls and study DD with two versions of the task. We found that SZ showed steeper discounting than HC and BP on the well-validated Kirby DD task. SZ showed no difference than HC on a separate DD task with smaller rewards presented with decimal places and shorter delays. As a preliminary finding, DD was found to be positively related to positive symptoms in FE SZ, while no relationship was found between negative symptoms and DD. In addition, we found comparable DD in BP compared to HC. Ultimately, our data may help elucidate the psychopathology in SZ and BP during intertemporal decision making.
KW - Delay discounting
KW - First-episode bipolar disorder
KW - First-episode schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85077304152&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077304152&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2019.11.063
DO - 10.1016/j.schres.2019.11.063
M3 - Article
AN - SCOPUS:85077304152
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -