Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval

Maureen Ritchey, Maria E. Montchal, Andrew P. Yonelinas, Charan Ranganath

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences.

Original languageEnglish (US)
JournaleLife
Volume4
DOIs
StatePublished - 2015

Fingerprint

Episodic Memory
Temporal Lobe
Hippocampus
Data storage equipment
Functional neuroimaging
Functional Neuroimaging
Aptitude
Recognition (Psychology)

Keywords

  • consolidation
  • fMRI
  • human
  • multi-voxel pattern analysis
  • neuroscience
  • recognition memory
  • representational similarity analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval. / Ritchey, Maureen; Montchal, Maria E.; Yonelinas, Andrew P.; Ranganath, Charan.

In: eLife, Vol. 4, 2015.

Research output: Contribution to journalArticle

Ritchey, Maureen ; Montchal, Maria E. ; Yonelinas, Andrew P. ; Ranganath, Charan. / Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval. In: eLife. 2015 ; Vol. 4.
@article{2864a0b8869e4bf6be9e5f4108a2c516,
title = "Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval",
abstract = "The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences.",
keywords = "consolidation, fMRI, human, multi-voxel pattern analysis, neuroscience, recognition memory, representational similarity analysis",
author = "Maureen Ritchey and Montchal, {Maria E.} and Yonelinas, {Andrew P.} and Charan Ranganath",
year = "2015",
doi = "10.7554/eLife.05025",
language = "English (US)",
volume = "4",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

TY - JOUR

T1 - Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval

AU - Ritchey, Maureen

AU - Montchal, Maria E.

AU - Yonelinas, Andrew P.

AU - Ranganath, Charan

PY - 2015

Y1 - 2015

N2 - The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences.

AB - The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences.

KW - consolidation

KW - fMRI

KW - human

KW - multi-voxel pattern analysis

KW - neuroscience

KW - recognition memory

KW - representational similarity analysis

UR - http://www.scopus.com/inward/record.url?scp=84992003378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992003378&partnerID=8YFLogxK

U2 - 10.7554/eLife.05025

DO - 10.7554/eLife.05025

M3 - Article

C2 - 25584461

AN - SCOPUS:84992003378

VL - 4

JO - eLife

JF - eLife

SN - 2050-084X

ER -