Degradation of insulin-like growth factors in small intestine of suckling rats

A. M. Fellah, Anthony F Philipps, T. J. Gillespie, J. R. Galo, B. Dvořák

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Insulin-like growth factors (IFGs), IGF-I and IGF-II, present in mammalian milk, play an important role during gastrointestinal tract development. In this study we identified and localized the activities of the common intestinal proteolytic enzymes and investigated their degradation effect on IGFs. Results indicated that the enzymatic activities of chymotrypsin, trypsin, and elastase progressed from the lowest in the duodenum, to the highest in the midjejunum, and declined in the ileum. Chymotrypsin exhibited the greatest IGFs degradation activities in neonatal intestinal lumen followed by elastase. These data furnish a potential strategic design to supplement IGFs into milk formulas.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalRegulatory Peptides
Volume98
Issue number1-2
DOIs
StatePublished - Apr 2 2001

Keywords

  • Degradation
  • Enzyme activation
  • Insulin-like growth factors

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

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