Degradation kinetics of a high porosity biodegradable scaffold

J. S. McKinney, K. A. Athanasiou, C. M. Agrawal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Porous poly(lactic-glycolic) acid (PLG) implants were fabricated using a modified salt-leaching technique. The in vitro degradation characteristics of these implants were then examined over 8 week period. The increase in dimensions of the implants between weeks 3 and 4 was due to polymer swelling. With time, this increase was overtaken by a loss in dimensions due to mass loss, which increased significantly after week 4. The implants exhibited a high level of degradation by week 8. The fabrication technique yielded highly porous implants with significant permeability. These characteristics make such implants ideal candidates for use as scaffolds for repair or regeneration of tissues.

Original languageEnglish (US)
Title of host publicationSouthern Biomedical Engineering Conference - Proceedings
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages18
Number of pages1
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Other

OtherProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

Fingerprint

Scaffolds
Porosity
Degradation
Kinetics
Lactic acid
Leaching
Swelling
Repair
Tissue
Salts
Fabrication
Polymers

ASJC Scopus subject areas

  • Engineering(all)

Cite this

McKinney, J. S., Athanasiou, K. A., & Agrawal, C. M. (1998). Degradation kinetics of a high porosity biodegradable scaffold. In Southern Biomedical Engineering Conference - Proceedings (pp. 18). Piscataway, NJ, United States: IEEE.

Degradation kinetics of a high porosity biodegradable scaffold. / McKinney, J. S.; Athanasiou, K. A.; Agrawal, C. M.

Southern Biomedical Engineering Conference - Proceedings. Piscataway, NJ, United States : IEEE, 1998. p. 18.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

McKinney, JS, Athanasiou, KA & Agrawal, CM 1998, Degradation kinetics of a high porosity biodegradable scaffold. in Southern Biomedical Engineering Conference - Proceedings. IEEE, Piscataway, NJ, United States, pp. 18, Proceedings of the 1998 17th Southern Biomedical Engineering Conference, San Antonio, TX, USA, 2/6/98.
McKinney JS, Athanasiou KA, Agrawal CM. Degradation kinetics of a high porosity biodegradable scaffold. In Southern Biomedical Engineering Conference - Proceedings. Piscataway, NJ, United States: IEEE. 1998. p. 18
McKinney, J. S. ; Athanasiou, K. A. ; Agrawal, C. M. / Degradation kinetics of a high porosity biodegradable scaffold. Southern Biomedical Engineering Conference - Proceedings. Piscataway, NJ, United States : IEEE, 1998. pp. 18
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