Degeneration in ACL injured knees with and without reconstruction in relation to muscle size and fat content-data from the osteoarthritis initiative

Pia M. Jungmann, Thomas Baum, Michael C. Nevitt, Lorenzo Nardo, Alexandra S. Gersing, Nancy E Lane, Charles E. McCulloch, Ernst J. Rummeny, Thomas M. Link

Research output: Contribution to journalArticle

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Abstract

Background: Anterior cruciate ligaments (ACL) injuries represent a major risk factor for early osteoarthritis (OA). Purpose: To evaluate the prevalence and 4-year progression of knee OA measured with 3T MR-imaging in individuals with ruptured, reconstructed or normal ACL and to assess the impact of thigh muscle characteristics. Methods: A total of 54 knees (23/54 male, 31/54 female) were recruited from the Osteoarthritis Initiative (OAI). At baseline, 15/54 subjects had prevalent ACL ruptures and 15/54 subjects had prevalent ACL reconstruction (24/54 normal ACL). Western Ontario and McMasters Universities Arthritis Index (WOMAC) scores, Physical Activity Scores of the Elderly (PASE) and thigh muscle characteristics including strength, fat infiltration (Goutallier score) and thigh muscle cross-sectional area (CSA) MR measurements were obtained at baseline. Wholeorgan MR-imaging Scores (WORMS) were obtained at baseline and at a 4-year follow-up time-point. Multivariate regression models, adjusting for covariates (age, gender, body mass index), were used for statistical analysis. Results: At baseline, subjects with prevalent ACL ruptures had worse WORMS total scores (mean ±SEM, 44.1±3.5) than subjects with ACL reconstruction (30.8±4.0; P = 0.015) and worse than subjects with normal ACL (21.3±3.0; P<0.001). Cartilage scores were worse in both femorotibial compartments in ACL injured knees than in knees with normal ACL (P<0.05). Knees with ACL reconstruction showed an increased degeneration of the medial meniscus (P = 0.036), cartilage degeneration at the medial femoral condyle (P = 0.011). In a multivariate regression model, including both ACL groups and total muscle characteristics as influence parameters, high thigh muscle CSA, high muscle/fat ratio and low Goutallier scores were associated with less degenerative changes at the knee, independent of ACL status. Knees with ACL reconstruction showed an increased progression of cartilage degeneration at the medial tibia compared to the normal ACL group (P = 0.027). Conclusions: High thigh muscle CSA is associated with less degenerative changes at the knee, independent of the ACL status and may potentially be advantageous in the prevention of early OA.

Original languageEnglish (US)
Article numbere0166865
JournalPLoS One
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2016

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anterior cruciate ligament
Anterior Cruciate Ligament
osteoarthritis
Ligaments
knees
Osteoarthritis
Muscle
Knee
Fats
lipid content
Muscles
muscles
Thigh
Anterior Cruciate Ligament Reconstruction
thighs
Cartilage
cartilage
Rupture
image analysis
Imaging techniques

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Degeneration in ACL injured knees with and without reconstruction in relation to muscle size and fat content-data from the osteoarthritis initiative. / Jungmann, Pia M.; Baum, Thomas; Nevitt, Michael C.; Nardo, Lorenzo; Gersing, Alexandra S.; Lane, Nancy E; McCulloch, Charles E.; Rummeny, Ernst J.; Link, Thomas M.

In: PLoS One, Vol. 11, No. 12, e0166865, 01.12.2016.

Research output: Contribution to journalArticle

Jungmann, Pia M. ; Baum, Thomas ; Nevitt, Michael C. ; Nardo, Lorenzo ; Gersing, Alexandra S. ; Lane, Nancy E ; McCulloch, Charles E. ; Rummeny, Ernst J. ; Link, Thomas M. / Degeneration in ACL injured knees with and without reconstruction in relation to muscle size and fat content-data from the osteoarthritis initiative. In: PLoS One. 2016 ; Vol. 11, No. 12.
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abstract = "Background: Anterior cruciate ligaments (ACL) injuries represent a major risk factor for early osteoarthritis (OA). Purpose: To evaluate the prevalence and 4-year progression of knee OA measured with 3T MR-imaging in individuals with ruptured, reconstructed or normal ACL and to assess the impact of thigh muscle characteristics. Methods: A total of 54 knees (23/54 male, 31/54 female) were recruited from the Osteoarthritis Initiative (OAI). At baseline, 15/54 subjects had prevalent ACL ruptures and 15/54 subjects had prevalent ACL reconstruction (24/54 normal ACL). Western Ontario and McMasters Universities Arthritis Index (WOMAC) scores, Physical Activity Scores of the Elderly (PASE) and thigh muscle characteristics including strength, fat infiltration (Goutallier score) and thigh muscle cross-sectional area (CSA) MR measurements were obtained at baseline. Wholeorgan MR-imaging Scores (WORMS) were obtained at baseline and at a 4-year follow-up time-point. Multivariate regression models, adjusting for covariates (age, gender, body mass index), were used for statistical analysis. Results: At baseline, subjects with prevalent ACL ruptures had worse WORMS total scores (mean ±SEM, 44.1±3.5) than subjects with ACL reconstruction (30.8±4.0; P = 0.015) and worse than subjects with normal ACL (21.3±3.0; P<0.001). Cartilage scores were worse in both femorotibial compartments in ACL injured knees than in knees with normal ACL (P<0.05). Knees with ACL reconstruction showed an increased degeneration of the medial meniscus (P = 0.036), cartilage degeneration at the medial femoral condyle (P = 0.011). In a multivariate regression model, including both ACL groups and total muscle characteristics as influence parameters, high thigh muscle CSA, high muscle/fat ratio and low Goutallier scores were associated with less degenerative changes at the knee, independent of ACL status. Knees with ACL reconstruction showed an increased progression of cartilage degeneration at the medial tibia compared to the normal ACL group (P = 0.027). Conclusions: High thigh muscle CSA is associated with less degenerative changes at the knee, independent of the ACL status and may potentially be advantageous in the prevention of early OA.",
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T1 - Degeneration in ACL injured knees with and without reconstruction in relation to muscle size and fat content-data from the osteoarthritis initiative

AU - Jungmann, Pia M.

AU - Baum, Thomas

AU - Nevitt, Michael C.

AU - Nardo, Lorenzo

AU - Gersing, Alexandra S.

AU - Lane, Nancy E

AU - McCulloch, Charles E.

AU - Rummeny, Ernst J.

AU - Link, Thomas M.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: Anterior cruciate ligaments (ACL) injuries represent a major risk factor for early osteoarthritis (OA). Purpose: To evaluate the prevalence and 4-year progression of knee OA measured with 3T MR-imaging in individuals with ruptured, reconstructed or normal ACL and to assess the impact of thigh muscle characteristics. Methods: A total of 54 knees (23/54 male, 31/54 female) were recruited from the Osteoarthritis Initiative (OAI). At baseline, 15/54 subjects had prevalent ACL ruptures and 15/54 subjects had prevalent ACL reconstruction (24/54 normal ACL). Western Ontario and McMasters Universities Arthritis Index (WOMAC) scores, Physical Activity Scores of the Elderly (PASE) and thigh muscle characteristics including strength, fat infiltration (Goutallier score) and thigh muscle cross-sectional area (CSA) MR measurements were obtained at baseline. Wholeorgan MR-imaging Scores (WORMS) were obtained at baseline and at a 4-year follow-up time-point. Multivariate regression models, adjusting for covariates (age, gender, body mass index), were used for statistical analysis. Results: At baseline, subjects with prevalent ACL ruptures had worse WORMS total scores (mean ±SEM, 44.1±3.5) than subjects with ACL reconstruction (30.8±4.0; P = 0.015) and worse than subjects with normal ACL (21.3±3.0; P<0.001). Cartilage scores were worse in both femorotibial compartments in ACL injured knees than in knees with normal ACL (P<0.05). Knees with ACL reconstruction showed an increased degeneration of the medial meniscus (P = 0.036), cartilage degeneration at the medial femoral condyle (P = 0.011). In a multivariate regression model, including both ACL groups and total muscle characteristics as influence parameters, high thigh muscle CSA, high muscle/fat ratio and low Goutallier scores were associated with less degenerative changes at the knee, independent of ACL status. Knees with ACL reconstruction showed an increased progression of cartilage degeneration at the medial tibia compared to the normal ACL group (P = 0.027). Conclusions: High thigh muscle CSA is associated with less degenerative changes at the knee, independent of the ACL status and may potentially be advantageous in the prevention of early OA.

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