Definition of human autoimmunity - autoantibodies versus autoimmune disease

Ana Lleo, Pietro Invernizzi, Bin Gao, Mauro Podda, M. Eric Gershwin

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

The critical function of the immune system is to discriminate self from non-self. Tolerance against self-antigens is a highly regulated process and, in order to maintain it, the immune system must be able to distinguish self-reactive lymphocytes as they develop. The presence of autoantibodies is the consequence of breakdown of tolerance and, although they are an important serological feature of autoimmune diseases, their presence is not exclusive of these conditions. Antibodies against self-antigens are also found in cancer, during massive tissue damage and even in healthy subjects. Natural autoantibodies provide immediate protection against infection and also prevent inflammation by facilitating the clearance of oxidized lipids, oxidized proteins, and apoptotic cells; their role in development of autoimmunity is still unclear. Detection of serum autoantibodies in clinical practice has become more available to clinicians worldwide while providing a powerful diagnostic tool. This review discusses the clinical significance of autoantibodies, their pathogenic mechanisms in autoimmune diseases and, finally, illustrates the technology available for appropriate autoantibody detection.

Original languageEnglish (US)
JournalAutoimmunity Reviews
Volume9
Issue number5
DOIs
StatePublished - Mar 2010

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Autoimmunity
Autoantibodies
Autoimmune Diseases
Autoantigens
Immune System
Healthy Volunteers
Lymphocytes
Inflammation
Technology
Lipids
Antibodies
Infection
Serum
Neoplasms
Proteins

Keywords

  • Autoantibody
  • Autoantigen
  • Autoimmune disease
  • B cell
  • Tolerance

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Definition of human autoimmunity - autoantibodies versus autoimmune disease. / Lleo, Ana; Invernizzi, Pietro; Gao, Bin; Podda, Mauro; Gershwin, M. Eric.

In: Autoimmunity Reviews, Vol. 9, No. 5, 03.2010.

Research output: Contribution to journalArticle

Lleo, Ana ; Invernizzi, Pietro ; Gao, Bin ; Podda, Mauro ; Gershwin, M. Eric. / Definition of human autoimmunity - autoantibodies versus autoimmune disease. In: Autoimmunity Reviews. 2010 ; Vol. 9, No. 5.
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