Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice

Jefferson W. Kinney, Grzegorz Starosta, Andrew Holmes, Craige C. Wrenn, Rebecca J. Yang, Ashley P. Harris, Katharine C. Long, Jacqueline Crawley

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Galanin inhibits the release of several neurotransmitters and produces performance deficits in a variety of spatial and aversive learning and memory tasks. The experiments in this study investigated the role galanin has in emotional learning and memory using a standard delay cued and contextual fear conditioning task. Rats were administered galanin into the lateral ventricles before training, and scored for freezing behavior in the same context and in a novel context with and without an auditory cue (CS) that had been paired previously with an aversive stimulus (US). Galanin-overexpressing transgenic mice were tested in an identical behavioral protocol. The galanin-administered rats and the transgenic mice were not significantly different from their respective controls on this task. A more challenging trace cued and contextual fear conditioning procedure was administered to separate groups of galanin-treated rats and galanin-overexpressing transgenic mice. Subjects were trained with the same CS and US, however, a 2.5-sec delay was inserted between CS offset and US onset. Following the trace conditioning, rats administered galanin and mice overexpressing galanin both exhibited significantly less freezing to the CS in the novel context as compared with their control groups. These results indicate that the observed disruption of cued fear conditioning was specific to the more difficult trace conditioning task. These findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks.

Original languageEnglish (US)
Pages (from-to)178-190
Number of pages13
JournalLearning and Memory
Volume9
Issue number4
DOIs
StatePublished - Jul 2002
Externally publishedYes

Fingerprint

Galanin
Transgenic Mice
Fear
Freezing
Conditioning (Psychology)
Lateral Ventricles
Cues
Neurotransmitter Agents
Learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice. / Kinney, Jefferson W.; Starosta, Grzegorz; Holmes, Andrew; Wrenn, Craige C.; Yang, Rebecca J.; Harris, Ashley P.; Long, Katharine C.; Crawley, Jacqueline.

In: Learning and Memory, Vol. 9, No. 4, 07.2002, p. 178-190.

Research output: Contribution to journalArticle

Kinney, JW, Starosta, G, Holmes, A, Wrenn, CC, Yang, RJ, Harris, AP, Long, KC & Crawley, J 2002, 'Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice', Learning and Memory, vol. 9, no. 4, pp. 178-190. https://doi.org/10.1101/m.49502
Kinney, Jefferson W. ; Starosta, Grzegorz ; Holmes, Andrew ; Wrenn, Craige C. ; Yang, Rebecca J. ; Harris, Ashley P. ; Long, Katharine C. ; Crawley, Jacqueline. / Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice. In: Learning and Memory. 2002 ; Vol. 9, No. 4. pp. 178-190.
@article{79d8e3d2082048d5b2c8cd03a4263e1c,
title = "Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice",
abstract = "Galanin inhibits the release of several neurotransmitters and produces performance deficits in a variety of spatial and aversive learning and memory tasks. The experiments in this study investigated the role galanin has in emotional learning and memory using a standard delay cued and contextual fear conditioning task. Rats were administered galanin into the lateral ventricles before training, and scored for freezing behavior in the same context and in a novel context with and without an auditory cue (CS) that had been paired previously with an aversive stimulus (US). Galanin-overexpressing transgenic mice were tested in an identical behavioral protocol. The galanin-administered rats and the transgenic mice were not significantly different from their respective controls on this task. A more challenging trace cued and contextual fear conditioning procedure was administered to separate groups of galanin-treated rats and galanin-overexpressing transgenic mice. Subjects were trained with the same CS and US, however, a 2.5-sec delay was inserted between CS offset and US onset. Following the trace conditioning, rats administered galanin and mice overexpressing galanin both exhibited significantly less freezing to the CS in the novel context as compared with their control groups. These results indicate that the observed disruption of cued fear conditioning was specific to the more difficult trace conditioning task. These findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks.",
author = "Kinney, {Jefferson W.} and Grzegorz Starosta and Andrew Holmes and Wrenn, {Craige C.} and Yang, {Rebecca J.} and Harris, {Ashley P.} and Long, {Katharine C.} and Jacqueline Crawley",
year = "2002",
month = "7",
doi = "10.1101/m.49502",
language = "English (US)",
volume = "9",
pages = "178--190",
journal = "Learning and Memory",
issn = "1072-0502",
publisher = "Cold Spring Harbor Laboratory Press",
number = "4",

}

TY - JOUR

T1 - Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice

AU - Kinney, Jefferson W.

AU - Starosta, Grzegorz

AU - Holmes, Andrew

AU - Wrenn, Craige C.

AU - Yang, Rebecca J.

AU - Harris, Ashley P.

AU - Long, Katharine C.

AU - Crawley, Jacqueline

PY - 2002/7

Y1 - 2002/7

N2 - Galanin inhibits the release of several neurotransmitters and produces performance deficits in a variety of spatial and aversive learning and memory tasks. The experiments in this study investigated the role galanin has in emotional learning and memory using a standard delay cued and contextual fear conditioning task. Rats were administered galanin into the lateral ventricles before training, and scored for freezing behavior in the same context and in a novel context with and without an auditory cue (CS) that had been paired previously with an aversive stimulus (US). Galanin-overexpressing transgenic mice were tested in an identical behavioral protocol. The galanin-administered rats and the transgenic mice were not significantly different from their respective controls on this task. A more challenging trace cued and contextual fear conditioning procedure was administered to separate groups of galanin-treated rats and galanin-overexpressing transgenic mice. Subjects were trained with the same CS and US, however, a 2.5-sec delay was inserted between CS offset and US onset. Following the trace conditioning, rats administered galanin and mice overexpressing galanin both exhibited significantly less freezing to the CS in the novel context as compared with their control groups. These results indicate that the observed disruption of cued fear conditioning was specific to the more difficult trace conditioning task. These findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks.

AB - Galanin inhibits the release of several neurotransmitters and produces performance deficits in a variety of spatial and aversive learning and memory tasks. The experiments in this study investigated the role galanin has in emotional learning and memory using a standard delay cued and contextual fear conditioning task. Rats were administered galanin into the lateral ventricles before training, and scored for freezing behavior in the same context and in a novel context with and without an auditory cue (CS) that had been paired previously with an aversive stimulus (US). Galanin-overexpressing transgenic mice were tested in an identical behavioral protocol. The galanin-administered rats and the transgenic mice were not significantly different from their respective controls on this task. A more challenging trace cued and contextual fear conditioning procedure was administered to separate groups of galanin-treated rats and galanin-overexpressing transgenic mice. Subjects were trained with the same CS and US, however, a 2.5-sec delay was inserted between CS offset and US onset. Following the trace conditioning, rats administered galanin and mice overexpressing galanin both exhibited significantly less freezing to the CS in the novel context as compared with their control groups. These results indicate that the observed disruption of cued fear conditioning was specific to the more difficult trace conditioning task. These findings are the first demonstration that galanin impairs performance on an emotional memory task and support the hypothesis that galanin-induced deficits are specific to more difficult cognitive tasks.

UR - http://www.scopus.com/inward/record.url?scp=0036667156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036667156&partnerID=8YFLogxK

U2 - 10.1101/m.49502

DO - 10.1101/m.49502

M3 - Article

C2 - 12177231

AN - SCOPUS:0036667156

VL - 9

SP - 178

EP - 190

JO - Learning and Memory

JF - Learning and Memory

SN - 1072-0502

IS - 4

ER -