Deficit of inhibitory glycine receptors in spinal cord from Peruvian Pasos: evidence for an equine form of inherited myoclonus

Andrew L. Gundlach, Gregg Kortz, Tanya C D Burazin, John E Madigan, Robert Higgins

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Inherited myoclonus in Poll Hereford calves and spasticity in the spastic mouse (spa/spa) are characterized by myoclonic jerks of the skeletal musculature which occur spontaneously and in response to sensory stimuli, symptoms resembling those in subconvulsive strychnine poisoning. The primary, biochemical defect in these myoclonic animals is a deficit of inhibitory glycine receptors in the central nervous system. We now report the occurrence of similar stimulus-induced myoclonus in individual, pure-bred Peruvian Paso horses and an associated, specific deficiency in the density of [3H]strychnine binding to inhibitory glycine receptors sites in spinal cord of these animals. Specificity of the deficit was confirmed by a demonstrated lack of change in the density of several other receptor types in affected spinal cord, including muscarinic receptors and GABAA/benzodiazepine receptors. In light of the existence of genetically-inherited myoclonus in other species, these results suggest the occurrence of an equine form of the disorder.

Original languageEnglish (US)
Pages (from-to)263-270
Number of pages8
JournalBrain Research
Volume628
Issue number1-2
DOIs
StatePublished - Nov 19 1993

Fingerprint

Glycine Receptors
Myoclonus
Horses
Spinal Cord
Strychnine
GABA-A Receptors
Muscle Spasticity
Muscarinic Receptors
Poisoning
Central Nervous System

Keywords

  • Equine
  • Inherited myoclonus
  • Inhibitory glycine receptor
  • Peruvian Paso
  • [H]Strychnine

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Deficit of inhibitory glycine receptors in spinal cord from Peruvian Pasos : evidence for an equine form of inherited myoclonus. / Gundlach, Andrew L.; Kortz, Gregg; Burazin, Tanya C D; Madigan, John E; Higgins, Robert.

In: Brain Research, Vol. 628, No. 1-2, 19.11.1993, p. 263-270.

Research output: Contribution to journalArticle

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