Abstract
Pyrroline-5-carboxylate synthase activity of the intestinal mucosa of cats was compared to that of rats and found to be only 18% as high per gram of mucosa and only 5% as high per kilogram body weight. This severe limitation in the first step in the de novo synthesis or ornithine may be the metabolic basis for the severe hyperammonemia found in cats fed an arginine-deficient diet. This lack of ornithine synthesis makes the cat completely dependent on dietary arginine for the ornithine required for the removal of ammonia via urea synthesis in the liver.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 146-150 |
| Number of pages | 5 |
| Journal | Journal of Nutrition |
| Volume | 115 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Deficiency of pyrroline-5-carboxylate synthase in the intestinal mucosa of the cat. / Rogers, Quinton; Phang, J. M.
In: Journal of Nutrition, Vol. 115, No. 1, 01.01.1985, p. 146-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Deficiency of pyrroline-5-carboxylate synthase in the intestinal mucosa of the cat
AU - Rogers, Quinton
AU - Phang, J. M.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Pyrroline-5-carboxylate synthase activity of the intestinal mucosa of cats was compared to that of rats and found to be only 18% as high per gram of mucosa and only 5% as high per kilogram body weight. This severe limitation in the first step in the de novo synthesis or ornithine may be the metabolic basis for the severe hyperammonemia found in cats fed an arginine-deficient diet. This lack of ornithine synthesis makes the cat completely dependent on dietary arginine for the ornithine required for the removal of ammonia via urea synthesis in the liver.
AB - Pyrroline-5-carboxylate synthase activity of the intestinal mucosa of cats was compared to that of rats and found to be only 18% as high per gram of mucosa and only 5% as high per kilogram body weight. This severe limitation in the first step in the de novo synthesis or ornithine may be the metabolic basis for the severe hyperammonemia found in cats fed an arginine-deficient diet. This lack of ornithine synthesis makes the cat completely dependent on dietary arginine for the ornithine required for the removal of ammonia via urea synthesis in the liver.
UR - http://www.scopus.com/inward/record.url?scp=0021986944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021986944&partnerID=8YFLogxK
U2 - 10.1093/jn/115.1.146
DO - 10.1093/jn/115.1.146
M3 - Article
C2 - 3965666
AN - SCOPUS:0021986944
VL - 115
SP - 146
EP - 150
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 1
ER -