Deficiency of interferon-γ but not interferon-β in Arabian foals with severe combined immunodeficiency

Tilahun Yilma, L. E. Perryman, T. C. McGuire

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The results of a study on the induction of IFN-α, IFN-β, and IFN-γ in normal and SCID foals showed a deficiency of IFN-γ but not IFN-β in SCID foals. The ability of SCID mononuclear cells to produce IFN-α in response to poly I:C but not to NDV may indicate a partial deficiency of IFN-α in SCID foals. The deficiency of IFN-γ and presence of IFN-β in SCID foals supports the classification of IFN-γ and IFN-β as immune and nonimmune interferons, respectively. Furthermore, the deficiency of IFN-γ in SCID foals may in part explain the high susceptibility to infections observed in SCID foals.

Original languageEnglish (US)
Pages (from-to)931-933
Number of pages3
JournalJournal of Immunology
Volume129
Issue number3
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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