The results of a study on the induction of IFN-α, IFN-β, and IFN-γ in normal and SCID foals showed a deficiency of IFN-γ but not IFN-β in SCID foals. The ability of SCID mononuclear cells to produce IFN-α in response to poly I:C but not to NDV may indicate a partial deficiency of IFN-α in SCID foals. The deficiency of IFN-γ and presence of IFN-β in SCID foals supports the classification of IFN-γ and IFN-β as immune and nonimmune interferons, respectively. Furthermore, the deficiency of IFN-γ in SCID foals may in part explain the high susceptibility to infections observed in SCID foals.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Immunology|
|State||Published - 1982|
ASJC Scopus subject areas