Deferoxamine injection does not affect bleomycin-induced lung fibrosis in rats

Carroll E Cross, Darren Warren, Joan E. Gerriets, Dennis W Wilson, Barry Halliwell, Jerold A Last

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Bleomycin is an antineoplastic agent that causes a dose-related lung fibrosis that limits its therapeutic effectiveness. It has been proposed that the cellula toxicity and antitumor effects of bleomycin occur by formation of O2-Fe(II)-bleomycin complexes that degrade DNA and release O2 - and OH radicals that attack other cellular components. Twice daily injections of the iron chelator deferoxamine were utilized in an attempt to amellorate bleomycin-induced lung fibrosis. They failed to diminish bleomycin-induced lung inflammation and fibrosis in rats.

Original languageEnglish (US)
Pages (from-to)428-432
Number of pages5
JournalThe Journal of Laboratory and Clinical Medicine
Volume106
Issue number4
StatePublished - 1985

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ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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