Bleomycin is an antineoplastic agent that causes a dose-related lung fibrosis that limits its therapeutic effectiveness. It has been proposed that the cellula toxicity and antitumor effects of bleomycin occur by formation of O2-Fe(II)-bleomycin complexes that degrade DNA and release O2 - and OH radicals that attack other cellular components. Twice daily injections of the iron chelator deferoxamine were utilized in an attempt to amellorate bleomycin-induced lung fibrosis. They failed to diminish bleomycin-induced lung inflammation and fibrosis in rats.
|Original language||English (US)|
|Number of pages||5|
|Journal||The Journal of Laboratory and Clinical Medicine|
|State||Published - 1985|
ASJC Scopus subject areas
- Pathology and Forensic Medicine