Decreases of cortical and thalamic glucose metabolism produced by parietal cortex stimulation in the rat

James W. Sharp, Manuel F. Gonzalez, Matthew T. Morton, Roger P. Simon, Frank R Sharp

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Parietal cortex stimulation elicited focal decreases as well as increases of brain glucose metabolism in ipsilateral cortex, ipsilateral thalamus, and contralateral cortex of rats in a pattern resembling 'surround inhibition'. It is proposed that parietal stimulation activated inhibitory circuits which decreased cortical and thalamic glucose metabolism. This decrease of cerebral glucose metabolism is important for interpreting brain glucose metabolic studies particularly when metabolic changes do not correlate with changes of neuronal activity.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalBrain Research
Volume438
Issue number1-2
DOIs
StatePublished - Jan 12 1988
Externally publishedYes

Keywords

  • Brain glucose metabolism
  • Cortex
  • Electrical stimulation
  • Inhibition
  • Selective attention
  • Sensory processing
  • Thalamic reticular nucleus
  • Thalamus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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