Decreased transforming growth factor beta1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. There is evidence of both immune dysregulation and autoimmune phenomena in autism. We examined the regulatory cytokine transforming growth factor beta-1 (TGFβ1) because of its role in controlling immune responses. Plasma levels of active TGFβ1 were evaluated in 75 children with ASD compared with 68 controls. Children with ASD had significantly lower plasma TGFβ1 levels compared with typically developing controls (p = 0.0017) and compared with children with developmental disabilities other than ASD (p = 0.0037), after adjusting for age and gender. In addition, there were significant correlations between psychological measures and TGFβ1 levels, such that lower TGFβ1 levels were associated with lower adaptive behaviors and worse behavioral symptoms. The data suggest that immune responses in autism may be inappropriately regulated due to reductions in TGFβ1. Such immune dysregulation may predispose to the development of possible autoimmune responses and/or adverse neuroimmune interactions during critical windows in development.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalJournal of Neuroimmunology
Volume204
Issue number1-2
DOIs
StatePublished - Nov 15 2008

Fingerprint

Transforming Growth Factor beta1
Autistic Disorder
Transforming Growth Factor beta
Behavioral Symptoms
Developmental Disabilities
Disabled Children
Psychological Adaptation
Interpersonal Relations
Autoimmunity
Communication
Cytokines
Psychology
Autism Spectrum Disorder

Keywords

  • Autism
  • Behavior
  • Immunity
  • Regulation
  • Transforming growth factor beta1

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

@article{bbff67cb634f4487928ccf7460a32a64,
title = "Decreased transforming growth factor beta1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes",
abstract = "Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. There is evidence of both immune dysregulation and autoimmune phenomena in autism. We examined the regulatory cytokine transforming growth factor beta-1 (TGFβ1) because of its role in controlling immune responses. Plasma levels of active TGFβ1 were evaluated in 75 children with ASD compared with 68 controls. Children with ASD had significantly lower plasma TGFβ1 levels compared with typically developing controls (p = 0.0017) and compared with children with developmental disabilities other than ASD (p = 0.0037), after adjusting for age and gender. In addition, there were significant correlations between psychological measures and TGFβ1 levels, such that lower TGFβ1 levels were associated with lower adaptive behaviors and worse behavioral symptoms. The data suggest that immune responses in autism may be inappropriately regulated due to reductions in TGFβ1. Such immune dysregulation may predispose to the development of possible autoimmune responses and/or adverse neuroimmune interactions during critical windows in development.",
keywords = "Autism, Behavior, Immunity, Regulation, Transforming growth factor beta1",
author = "Paul Ashwood and Amanda Enstrom and Paula Krakowiak and Irva Hertz-Picciotto and Hansen, {Robin L} and Croen, {Lisa A.} and Ozonoff, {Sally J} and Pessah, {Isaac N} and {Van de Water}, {Judith A}",
year = "2008",
month = "11",
day = "15",
doi = "10.1016/j.jneuroim.2008.07.006",
language = "English (US)",
volume = "204",
pages = "149--153",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Decreased transforming growth factor beta1 in autism

T2 - A potential link between immune dysregulation and impairment in clinical behavioral outcomes

AU - Ashwood, Paul

AU - Enstrom, Amanda

AU - Krakowiak, Paula

AU - Hertz-Picciotto, Irva

AU - Hansen, Robin L

AU - Croen, Lisa A.

AU - Ozonoff, Sally J

AU - Pessah, Isaac N

AU - Van de Water, Judith A

PY - 2008/11/15

Y1 - 2008/11/15

N2 - Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. There is evidence of both immune dysregulation and autoimmune phenomena in autism. We examined the regulatory cytokine transforming growth factor beta-1 (TGFβ1) because of its role in controlling immune responses. Plasma levels of active TGFβ1 were evaluated in 75 children with ASD compared with 68 controls. Children with ASD had significantly lower plasma TGFβ1 levels compared with typically developing controls (p = 0.0017) and compared with children with developmental disabilities other than ASD (p = 0.0037), after adjusting for age and gender. In addition, there were significant correlations between psychological measures and TGFβ1 levels, such that lower TGFβ1 levels were associated with lower adaptive behaviors and worse behavioral symptoms. The data suggest that immune responses in autism may be inappropriately regulated due to reductions in TGFβ1. Such immune dysregulation may predispose to the development of possible autoimmune responses and/or adverse neuroimmune interactions during critical windows in development.

AB - Autism spectrum disorders (ASD) are characterized by impairment in social interactions, communication deficits, and restricted repetitive interests and behaviors. There is evidence of both immune dysregulation and autoimmune phenomena in autism. We examined the regulatory cytokine transforming growth factor beta-1 (TGFβ1) because of its role in controlling immune responses. Plasma levels of active TGFβ1 were evaluated in 75 children with ASD compared with 68 controls. Children with ASD had significantly lower plasma TGFβ1 levels compared with typically developing controls (p = 0.0017) and compared with children with developmental disabilities other than ASD (p = 0.0037), after adjusting for age and gender. In addition, there were significant correlations between psychological measures and TGFβ1 levels, such that lower TGFβ1 levels were associated with lower adaptive behaviors and worse behavioral symptoms. The data suggest that immune responses in autism may be inappropriately regulated due to reductions in TGFβ1. Such immune dysregulation may predispose to the development of possible autoimmune responses and/or adverse neuroimmune interactions during critical windows in development.

KW - Autism

KW - Behavior

KW - Immunity

KW - Regulation

KW - Transforming growth factor beta1

UR - http://www.scopus.com/inward/record.url?scp=54349091759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54349091759&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2008.07.006

DO - 10.1016/j.jneuroim.2008.07.006

M3 - Article

C2 - 18762342

AN - SCOPUS:54349091759

VL - 204

SP - 149

EP - 153

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -