Decreased macular leukocyte velocity in human immunodeficiency virus-infected individuals

Michele C Lim, William G. Cumberland, Sonia L. Minassian, Susan S. Ransome, Michael J. Cornish, Brian G. Terry, Gary N. Holland

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

PURPOSE: To determine whether human immunodeficiency virus (HIV)-infected individuals have decreased macular capillary blood flow in vivo. DESIGN: Case control study. METHODS: Macular leukocyte velocity and perceived leukocyte density were determined in 41 HIV-infected individuals without cytomegalovirus retinitis and 31 HIV-negative control subjects using the blue field simulation technique (BFS-2000, Oculix, Inc., Jenkintown, PA). Velocity and density measurements for HIV-infected individuals were compared to current and lowest previous CD4+ T-lymphocyte counts, HIV RNA blood levels, and blood leukocyte counts.RESULTS: Mean macular leukocyte velocity was lower in HIV-infected individuals than in controls (P = 0.0006). No correlations were identified between velocity measurements and the following factors in HIV-infected individuals: current or lowest previous CD4+ T-lymphocyte count; or HIV RNA blood level. Mean perceived leukocyte density in HIV-infected individuals was lower than in controls (P = 0.003), but was not correlated with blood leukocyte count in HIV-infected individuals. No relationships were identified between macular leukocyte velocity and duration of medication use or duration of elevated CD4+ T-lymphocyte count in patients receiving potent antiretroviral therapy. CONCLUSIONS: Reduced macular leukocyte velocity may have important implications for understanding the retinal microvasculopathy of HIV disease, the pathogenesis of opportunistic retinal infections, and visual dysfunction in HIV-infected individuals who do not have opportunistic retinal infections. We found no evidence that macular leukocyte velocity increased with immune reconstitution.

Original languageEnglish (US)
Pages (from-to)711-719
Number of pages9
JournalAmerican Journal of Ophthalmology
Volume132
Issue number5
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Decreased macular leukocyte velocity in human immunodeficiency virus-infected individuals'. Together they form a unique fingerprint.

  • Cite this

    Lim, M. C., Cumberland, W. G., Minassian, S. L., Ransome, S. S., Cornish, M. J., Terry, B. G., & Holland, G. N. (2001). Decreased macular leukocyte velocity in human immunodeficiency virus-infected individuals. American Journal of Ophthalmology, 132(5), 711-719. https://doi.org/10.1016/S0002-9394(01)01201-6