Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder

Richard J Maddock; Dorothy W. Gietzen; Theodore A. Goodman

doi:10.1016/0165-0327(93)90115-Z

Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder

Richard J Maddock, Dorothy W. Gietzen, Theodore A. Goodman

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor function in 12 additional patients with PDA. Lower cyclic AMP responses to isoproterenol were significantly correlated with milder agoraphobia and better response to naturalistic treatment. Lower beta-receptor density tended to correlate similarly with agoraphobia and treatment response. These findings further support that decreased peripheral beta-receptor function in PDA reflects an adaptive process associated with greater resistance to agoraphobia and greater capacity for recovery with treatment.

Original language	English (US)
Pages (from-to)	27-32
Number of pages	6
Journal	Journal of Affective Disorders
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/0165-0327(93)90115-Z
State	Published - 1993

Keywords

Agoraphobia
Beta-adrenergic receptor
Lymphocyte
Panic disorder
Treatment

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

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10.1016/0165-0327(93)90115-Z

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title = "Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder",

abstract = "Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor function in 12 additional patients with PDA. Lower cyclic AMP responses to isoproterenol were significantly correlated with milder agoraphobia and better response to naturalistic treatment. Lower beta-receptor density tended to correlate similarly with agoraphobia and treatment response. These findings further support that decreased peripheral beta-receptor function in PDA reflects an adaptive process associated with greater resistance to agoraphobia and greater capacity for recovery with treatment.",

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