Abstract
Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor function in 12 additional patients with PDA. Lower cyclic AMP responses to isoproterenol were significantly correlated with milder agoraphobia and better response to naturalistic treatment. Lower beta-receptor density tended to correlate similarly with agoraphobia and treatment response. These findings further support that decreased peripheral beta-receptor function in PDA reflects an adaptive process associated with greater resistance to agoraphobia and greater capacity for recovery with treatment.
Original language | English (US) |
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Pages (from-to) | 27-32 |
Number of pages | 6 |
Journal | Journal of Affective Disorders |
Volume | 29 |
Issue number | 1 |
DOIs | |
State | Published - 1993 |
Keywords
- Agoraphobia
- Beta-adrenergic receptor
- Lymphocyte
- Panic disorder
- Treatment
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)