Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder

Richard J Maddock, Dorothy W. Gietzen, Theodore A. Goodman

Research output: Contribution to journalArticle

3 Scopus citations


Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor function in 12 additional patients with PDA. Lower cyclic AMP responses to isoproterenol were significantly correlated with milder agoraphobia and better response to naturalistic treatment. Lower beta-receptor density tended to correlate similarly with agoraphobia and treatment response. These findings further support that decreased peripheral beta-receptor function in PDA reflects an adaptive process associated with greater resistance to agoraphobia and greater capacity for recovery with treatment.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalJournal of Affective Disorders
Issue number1
StatePublished - 1993



  • Agoraphobia
  • Beta-adrenergic receptor
  • Lymphocyte
  • Panic disorder
  • Treatment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

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