Abstract
Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor function in 12 additional patients with PDA. Lower cyclic AMP responses to isoproterenol were significantly correlated with milder agoraphobia and better response to naturalistic treatment. Lower beta-receptor density tended to correlate similarly with agoraphobia and treatment response. These findings further support that decreased peripheral beta-receptor function in PDA reflects an adaptive process associated with greater resistance to agoraphobia and greater capacity for recovery with treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-32 |
| Number of pages | 6 |
| Journal | Journal of Affective Disorders |
| Volume | 29 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1993 |
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Keywords
- Agoraphobia
- Beta-adrenergic receptor
- Lymphocyte
- Panic disorder
- Treatment
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder. / Maddock, Richard J; Gietzen, Dorothy W.; Goodman, Theodore A.
In: Journal of Affective Disorders, Vol. 29, No. 1, 1993, p. 27-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Decreased lymphocyte beta-adrenoreceptor function correlates with less agoraphobia and better outcome in panic disorder
AU - Maddock, Richard J
AU - Gietzen, Dorothy W.
AU - Goodman, Theodore A.
PY - 1993
Y1 - 1993
N2 - Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor function in 12 additional patients with PDA. Lower cyclic AMP responses to isoproterenol were significantly correlated with milder agoraphobia and better response to naturalistic treatment. Lower beta-receptor density tended to correlate similarly with agoraphobia and treatment response. These findings further support that decreased peripheral beta-receptor function in PDA reflects an adaptive process associated with greater resistance to agoraphobia and greater capacity for recovery with treatment.
AB - Previous studies have demonstrated reduced function of peripheral beta-adrenoreceptors in panic disorder with agoraphobia (PDA). We recently reported that decreased lymphocyte beta-receptor function was associated with milder agoraphobia and better treatment response in PDA. We now report on lymphocyte beta-receptor function in 12 additional patients with PDA. Lower cyclic AMP responses to isoproterenol were significantly correlated with milder agoraphobia and better response to naturalistic treatment. Lower beta-receptor density tended to correlate similarly with agoraphobia and treatment response. These findings further support that decreased peripheral beta-receptor function in PDA reflects an adaptive process associated with greater resistance to agoraphobia and greater capacity for recovery with treatment.
KW - Agoraphobia
KW - Beta-adrenergic receptor
KW - Lymphocyte
KW - Panic disorder
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=0027202769&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027202769&partnerID=8YFLogxK
U2 - 10.1016/0165-0327(93)90115-Z
DO - 10.1016/0165-0327(93)90115-Z
M3 - Article
C2 - 8254140
AN - SCOPUS:0027202769
VL - 29
SP - 27
EP - 32
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1
ER -