Decreased levels of total immunoglobulin in children with autism are not a result of B cell dysfunction

Luke S. Heuer, Melissa Rose, Paul Ashwood, Judith A Van de Water

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Autism spectrum disorders are a heterogeneous group of behaviorally defined disorders having complex etiologies. We previously reported a direct correlation between lower plasma levels of the immunoglobulins (Ig) IgG and IgM and increased severity of behavioral symptoms in children with autism. Our current objective was to determine if these reduced plasma levels of IgG and IgM are the result of defective B cell development, activation, or function. Results suggest no differences in the B cell parameters measured, indicating that decreased Ig in autism is not a result of B cell dysfunction and other immune cells might be involved.

Original languageEnglish (US)
Pages (from-to)94-102
Number of pages9
JournalJournal of Neuroimmunology
Volume251
Issue number1-2
DOIs
StatePublished - Oct 15 2012

Keywords

  • Autism
  • B cell
  • Immune system
  • Immunoglobulin

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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