Decreased formation of prostaglandins derived from arachidonic acid by dietary linolenate in rats

D. H. Hwang, A. E. Carroll

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Accumulated evidence now suggests that availability of precursor acid is an important factor controlling the biosynthesis of prostaglandins (PG's). Since linolenic acid inhibits the conversion of linoleic acid to arachidonic acid (PGE2, PGF(2α) and thromboxane A2 precursor), rats receiving more linolenic acid are expected to have less arachidonic acid and thus less PG's synthesized from arachinodic acid than those receiving linoleic acid alone. Essential fatty acid-deficient rats, induced feeding hydrogenated coconut oil diet for 15 weeks, were divided into six groups and fed graded amounts of purified mthyl linolenate for 6 weeks. Each group of rats except essential fatty acid-deficient group received the same amount of linoleate. The results showed that the level of arachidonic acid in serum lipids and serum concentrations of PG's synthesized from arachidonic acid by platelets decreased as the amount of dietary linolenate increased. This indicated that biosynthesis of PG's in platelets can be influenced by the availability of precursors, and thus it can be modified by the manipulation of dietary fatty acids.

Original languageEnglish (US)
Pages (from-to)590-597
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Issue number3
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)


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