Decreased fetal weights in rats exposed to sidestream cigarette smoke

Padmanabhan Rajini, Jerold A Last, Kent E Pinkerton, Andrew G Hendrickx, Hanspeter Witschi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Pregnant Sprague-Dawley rats were exposed to sidestream Cigarette smoke (SS) for 6 hr a day, at a concentration of 1 mg/m3 of respirable total suspended particulate material (TSP) on Days 3, 6-10, and 13-17 of pregnancy. Controls were kept in an identical chamber without smoke exposure. The animals were killed on Day 20 of gestation. No differences were found in maternal body weight gain or average daily food consumption between the smoke-exposed and control groups. The numbers of fetuses and of implantation sites per litter were comparable among the groups. None of the pups showed any gross malformations and no difference was found between controls and SS-exposed pups when examined for reduced skeletal ossifications. However, there was a small but significant reduction in mean pup weight. We conclude that intermittent exposure of rats to sidestream cigarette smoke at concentrations severalfold greater than those encountered in smokey public indoor environments causes intrauterine growth retardation.

Original languageEnglish (US)
Pages (from-to)400-404
Number of pages5
JournalToxicological Sciences
Volume22
Issue number3
DOIs
StatePublished - Apr 1994

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Fetal Weight
Smoke
Tobacco Products
Rats
Pregnancy
Fetal Growth Retardation
Osteogenesis
Weight Gain
Sprague Dawley Rats
Animals
Fetus
Body Weight
Mothers
Weights and Measures
Food
Control Groups

ASJC Scopus subject areas

  • Molecular Biology
  • Embryology
  • Cell Biology
  • Genetics
  • Developmental Biology
  • Toxicology

Cite this

Decreased fetal weights in rats exposed to sidestream cigarette smoke. / Rajini, Padmanabhan; Last, Jerold A; Pinkerton, Kent E; Hendrickx, Andrew G; Witschi, Hanspeter.

In: Toxicological Sciences, Vol. 22, No. 3, 04.1994, p. 400-404.

Research output: Contribution to journalArticle

Rajini, Padmanabhan ; Last, Jerold A ; Pinkerton, Kent E ; Hendrickx, Andrew G ; Witschi, Hanspeter. / Decreased fetal weights in rats exposed to sidestream cigarette smoke. In: Toxicological Sciences. 1994 ; Vol. 22, No. 3. pp. 400-404.
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