Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia

John G. Kerns, Jonathan D. Cohen, Angus W. MacDonald, Melissa K. Johnson, V. Andrew Stenger, Howard Aizenstein, Cameron S Carter

Research output: Contribution to journalArticle

212 Citations (Scopus)

Abstract

Objective: People with schizophrenia have exhibited reduced functional activity in the anterior cingulate cortex during the performance of many types of cognitive tasks and during the commission of errors. According to conflict theory, the anterior cingulate cortex is involved in the monitoring of response conflict, acting as a signal for a need for greater cognitive control. This study examined whether impaired conflict monitoring in people with schizophrenia could underlie reduced anterior cingulate activity during both correct task performance and error-related activity. Method: Functional activity in the anterior cingulate of 13 schizophrenia patients and 13 healthy comparison subjects was investigated by using event-related fMRI and a Stroop task that allowed simultaneous examination of activity during both conflict (incongruent trials) and error (commission of error trials). Results: In the presence of comparable reaction time measures for conflict as well as comparable error rates, the schizophrenia subjects showed both decreased conflict- and error-related activity in the same region of the anterior cingulate cortex. Moreover, those with schizophrenia did not exhibit significant post-conflict or post-error behavioral adjustments. Conclusions: Concurrently reduced conflict- and error-related activity in the anterior cingulate cortex along with reduced trial-to-trial adjustments in performance has not previously been reported in schizophrenia. The current results suggest that impaired conflict monitoring by the anterior cingulate cortex might play an important role in contributing to cognitive control deficits in patients with schizophrenia.

Original languageEnglish (US)
Pages (from-to)1833-1839
Number of pages7
JournalAmerican Journal of Psychiatry
Volume162
Issue number10
DOIs
StatePublished - Oct 2005

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Gyrus Cinguli
Schizophrenia
Social Adjustment
Conflict (Psychology)
Task Performance and Analysis
Reaction Time
Healthy Volunteers
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia. / Kerns, John G.; Cohen, Jonathan D.; MacDonald, Angus W.; Johnson, Melissa K.; Stenger, V. Andrew; Aizenstein, Howard; Carter, Cameron S.

In: American Journal of Psychiatry, Vol. 162, No. 10, 10.2005, p. 1833-1839.

Research output: Contribution to journalArticle

Kerns, John G. ; Cohen, Jonathan D. ; MacDonald, Angus W. ; Johnson, Melissa K. ; Stenger, V. Andrew ; Aizenstein, Howard ; Carter, Cameron S. / Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia. In: American Journal of Psychiatry. 2005 ; Vol. 162, No. 10. pp. 1833-1839.
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