Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders

Charity Onore, Amanda Enstrom, Paula Krakowiak, Irva Hertz-Picciotto, Robin L Hansen, Judith A Van de Water, Paul Ashwood

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

A potential role for TH17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p = 0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of TH17 cells, a cell subset important in neuroinflammatory conditions that may include ASD.

Original languageEnglish (US)
Pages (from-to)126-129
Number of pages4
JournalJournal of Neuroimmunology
Volume216
Issue number1-2
DOIs
StatePublished - Nov 30 2009

Keywords

  • Autism spectrum disorders
  • IL-17
  • IL-23
  • Inflammation
  • Lymphocytes
  • T17 cells

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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