Decreased adiposity and enhanced glucose tolerance in shikonin treated mice

Ahmed Bettaieb, Ellen Hosein, Samah Chahed, Ahlam Abdulaziz, Heidi R. Kucera, Nilesh W. Gaikwad, Fawaz Haj

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective Obesity represents a major public health problem, and identifying natural compounds that modulate energy balance and glucose homeostasis is of interest for combating obesity and its associated disorders. The naphthoquinone shikonin has diverse beneficial properties including anti-inflammatory, anti-oxidant, and anti-microbial effects. The objective of this study is to investigate the effects of shikonin on adiposity and glucose homeostasis. Methods The metabolic effects of shikonin treatment on mice fed regular chow or challenged with a high-fat diet (HFD) were determined. Results Shikonin treated mice fed regular chow exhibited improved glucose tolerance compared with controls. In addition, shikonin treated mice fed HFD displayed decreased weight gain and resistance to HFD-induced glucose intolerance. Further, shikonin treatment decreased HFD-induced hepatic dyslipidemia. These findings correlated with enhanced hepatic insulin signaling in shikonin treated mice as evidenced by increased tyrosyl phosphorylation of the insulin receptor and enhanced downstream signaling. Conclusions These studies identify shikonin as a potential regulator of systemic glucose tolerance, energy balance, and adiposity in vivo.

Original languageEnglish (US)
Pages (from-to)2269-2277
Number of pages9
JournalObesity
Volume23
Issue number11
DOIs
StatePublished - Nov 1 2015

Fingerprint

Adiposity
Glucose
High Fat Diet
Homeostasis
Obesity
Naphthoquinones
Glucose Intolerance
shikonin
Liver
Insulin Receptor
Dyslipidemias
Oxidants
Weight Gain
Anti-Inflammatory Agents
Public Health
Phosphorylation
Insulin

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Bettaieb, A., Hosein, E., Chahed, S., Abdulaziz, A., Kucera, H. R., Gaikwad, N. W., & Haj, F. (2015). Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. Obesity, 23(11), 2269-2277. https://doi.org/10.1002/oby.21263

Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. / Bettaieb, Ahmed; Hosein, Ellen; Chahed, Samah; Abdulaziz, Ahlam; Kucera, Heidi R.; Gaikwad, Nilesh W.; Haj, Fawaz.

In: Obesity, Vol. 23, No. 11, 01.11.2015, p. 2269-2277.

Research output: Contribution to journalArticle

Bettaieb, A, Hosein, E, Chahed, S, Abdulaziz, A, Kucera, HR, Gaikwad, NW & Haj, F 2015, 'Decreased adiposity and enhanced glucose tolerance in shikonin treated mice', Obesity, vol. 23, no. 11, pp. 2269-2277. https://doi.org/10.1002/oby.21263
Bettaieb A, Hosein E, Chahed S, Abdulaziz A, Kucera HR, Gaikwad NW et al. Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. Obesity. 2015 Nov 1;23(11):2269-2277. https://doi.org/10.1002/oby.21263
Bettaieb, Ahmed ; Hosein, Ellen ; Chahed, Samah ; Abdulaziz, Ahlam ; Kucera, Heidi R. ; Gaikwad, Nilesh W. ; Haj, Fawaz. / Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. In: Obesity. 2015 ; Vol. 23, No. 11. pp. 2269-2277.
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