Decomposition rates of radiopharmaceutical indium chelates in serum

S. M. Yeh, C. F. Meares, D. A. Goodwin

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The rates at which six small aminopolycarboxylate chelates of trivalent111In and three protein-bound chelates of111In deliver indium to the serum protein transferrin have been studied in sterile human serum at pH 7.3, 37°C. Sterically hindered chelates containing a substituent on an ethylene carbon of EDTA decompose with rates in the range 0.03 to 0.11% per day-one to two orders of magnitude slower than other chelates. Only small differences are observed between rates of decomposition for low-molecular-weight chelates and for protein-bound chelates having analogous structures.

Original languageEnglish (US)
Pages (from-to)327-336
Number of pages10
JournalJournal of Radioanalytical Chemistry
Volume53
Issue number1-2
DOIs
StatePublished - Mar 1979

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Molecular Medicine

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