Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age

D. Vashishth, O. Verborgt, G. Divine, M. B. Schaffler, David P Fyhrie

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Despite osteocytes' ideal position to sense the local environment and thereby influence bone remodeling, the function of osteocytes in bone remains controversial. In this study, histomorphometric examination of male and female femoral middiaphyseal cortical bone was conducted to determine if bone's remodeling response, indicated by tissue porosity and accumulation of damage, is associated with osteocyte lacunar density (number of osteocyte lacunae per bone area). The results support the sensory role of the osteocyte network as the decline in osteocyte lacunar density in human cortical bone is associated with the accumulation of microcracks and increase in porosity with age. Porosity and microcrack density increased exponentially with a decline in osteocyte lacunar density indicating that a certain minimum number of osteocytes is essential for an 'operational' network. No gender-related differences were found in the relationship of osteocyte lacunar density to age, porosity, or microcrack density. The coefficient of variation of osteocyte lacunar density increased linearly with age, indicating that aging bone tissue is characterized by increased heterogeneity in the spatial organization of osteocytes. Osteocyte lacunar density, porosity, and microcrack density exhibited the same exponential probability density distribution in the donor population, indicating their regulation by similar biological phenomena. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)375-380
Number of pages6
JournalBone
Volume26
Issue number4
DOIs
StatePublished - Apr 2000
Externally publishedYes

Fingerprint

Osteocytes
Porosity
Bone Remodeling
Bone and Bones
Cortical Bone
Biological Phenomena
Proprioception
Thigh

Keywords

  • Aging
  • Cortical bone
  • Lacunae
  • Microcracks
  • Osteocyte
  • Porosity

ASJC Scopus subject areas

  • Physiology
  • Hematology

Cite this

Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age. / Vashishth, D.; Verborgt, O.; Divine, G.; Schaffler, M. B.; Fyhrie, David P.

In: Bone, Vol. 26, No. 4, 04.2000, p. 375-380.

Research output: Contribution to journalArticle

Vashishth, D. ; Verborgt, O. ; Divine, G. ; Schaffler, M. B. ; Fyhrie, David P. / Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age. In: Bone. 2000 ; Vol. 26, No. 4. pp. 375-380.
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